| Objectives It is mainly to collect clinical data,obtain large samples,and use the method of evidence-based medicine to analyze the prognosis of male breast cancer patients,so as to provide a certain theoretical basis for the formulation of standardized treatment plan.Methods Computer system was used to retrieve Pubmed,Embase,Cochrane library and other English databases,and Chinese databases such as CNKI,CBM and Wanfang databases.The literature on the prognostic factors affecting male breast cancer was searched by using a combination of subject words(Mes H table)+ free words,and the references were manually searched to ensure sufficient complete data.The time range since the search was conducted to November 2021 for published studies related to prognostic factors in male breast cancer.The Chinese search terms used are: "male breast cancer" and "prognostic factors",and the English search terms are "male breast cancer" and "prognosis"..Results A total of 20 literature,9 Chinese and 11 English,a total of 1468 patients were included.The published countries of the included literature were obtained from China,USA,Turkey,Brazil,Australia,Serbia,Egypt,and Pakistan.Survival data are available in all literature,with 12 article studies reporting 5-year overall survival and 5-year diseasefree survival data and 20 article studies reporting only 5-year overall survival data.The results showed that the effect on 5-year overall survival showed that TNM patients I-II had better prognosis than III-IV OR=0.17,95%CI:(0.12-0.24),The prognosis of patients with tumor diameter less than or equal to 5cm is better than that of patients with tumor diameter greater than 5cm OR=0.14,,95%CI:(0.10-0.21),Nonode negative patients had a better prognosis than those with positive nodes OR=0.23,95%CI:(0.16-0.34),The prognosis of patients with endocrine therapy is better than that of patients without endocrine therapy OR=0.49,95%CI:(0.35-0.68),The prognosis of patients with chemotherapy was better than that of patients without chemotherapy OR=0.4,95%CI:(0.3-0.54),The prognosis of operative patients is better than that of non-surgical patients OR=0.11,95%CI:(0.05-0.24),The prognosis of radical radical surgery is better than that of other surgical methods OR=0.17,95%CI:(0.07-0.46),Estrogen receptor expression status had no effect on prognosis OR=0.52,95%CI:(0.31-0.87),Positive prognosis is better than negative prognosis OR=0.50,95%CI:(0.30-0.84),The prognosis of histologic G1-2 patients was better than that of histological G3 patients OR=0.06,95%CI:(0.02-0.25).The effect on 5-year disease-free survival showed that patients with TNM stages I-II had a better prognosis than those with III-IV stages OR=0.16,95%CI:(0.11-0.24),The prognosis of patients with tum 6or diameter less than or equal to 5cm is better than that of patients with tumor diameter greater than 5cm OR=0.13,95%CI:(0.08-0.20),Nonode negative patients had a better prognosis than those with positive nodes OR=0.24,95%CI:(0.16-0.35),The prognosis of patients with endocrine therapy is better than that of patients without endocrine therapy OR=0.52,95%CI:(0.35-0.76),The prognosis of patients with chemotherapy was better than that of patients without chemotherapy OR=0.62,95%CI:(0.45-0.85).Conclusions 1 The 5-year overall survival of male breast cancer was related to TNM stage,primary tumor size,lymph node status,endocrine therapy,chemotherapy,estrogen receptor status,progesterone receptor status,surgery,surgical approach,and histological grade.2 The 5-year disease-free survival rate of male breast cancer is related to TNM stage,primary tumor size,lymph node status,endocrine therapy,and chemotherapy.There is no dispute that TNM stage,primary tumor size,and lymph node status are the prognostic factors in male breast cancer.At the same time,chemotherapy,endocrine therapy,surgery,surgical mode,estrogen receptor status,progesterone receptor status,and histological grade are also the prognostic factors of male breast cancer.Some related factors affecting male breast cancer prognosis have fewer sample sizes and were not further analyzed in subgroups,so more high-quality literature is needed to include the accuracy of the validation results later.Figure46;Table2;Reference167... |
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