| Objective: To observe the clinical efficacy and effects on pepsinogen(PG)andgastrin-17(G-17)levels of Weifukang Prescription in the treatment of(damp-heat syndrome)Hp-related chronic gastritis with intestinal metaplasia.Methods: Sixty-two patients with Hp-associated chronic gastritis with intestinal metaplasia who met the diagnostic criteria were included,and were divided into treatment and control groups according to the random number method,with 31 cases in each group.Both groups were treated with anti-Hp therapy for the first 2 weeks,and given bismuth-containing western medicine quadruple therapy.The treatment group was treated with Wei Fu Kang Prescription,and the control group was treated with Chinese medicine Wei Fu Kang capsule.At the end of the Hp eradication course,the western medicine was stopped,and the treatment group continued to take oral gastric fukang formula and the control group continued to take gastric fuchun capsule for 10 weeks.The treatment course was 12 weeks in total.At the end of the treatment course,the levels of TCM symptoms,Hp eradication,pathological histological score,serum index pepsinogen I(PGI),pepsinogen Ⅱ(PGⅡ),pepsinogen Ⅰ/Ⅱ(PGR)and gastrin-17(G-17)were observed and compared between the two groups before and after treatment.Results: The treatment group and the control group shed 2 cases and 1 case,respectively,and 29 cases in the treatment group and 30 cases in the control group completed the clinical study.(1)Chinese medicine clinical efficacy: the total effective rate of the treatment group(93.1%)was higher than that of the control group(70%),and the difference was statistically significant(P < 0.05).(2)TCM evidence points:(1)Total TCM evidence points: the total TCM evidence points of patients in both groups were statistically significant(P <0.01)compared with those before treatment.After treatment,the total points of TCM symptoms in the treatment group were lower than those in the control group,and the difference was statistically significant(P < 0.01),and the treatment group was better than the control group.(2)The individual points of TCM symptoms: after treatment,the points of stomach pain,flatulence,bitterness and bad breath,poor appetite,nausea and vomiting decreased in both groups compared with those before treatment,and the difference was statistically significant(P < 0.01),while the difference of loose stools and belching between the two groups was not statistically significant(P > 0.05).The difference was statistically significant(P < 0.05),and the treatment group was better than the control group in terms of stomach pain,fullness,bitterness and bad breath,poor appetite,nausea and vomiting.The differences in loose stools and belching between the two groups were not statistically significant(P > 0.05).(3)Hp eradication rate: the eradication rates of the control group and the treatment group were 63.3% and 86.2%,respectively,and the difference between the two groups was statistically significant(P < 0.05),and the efficacy of the treatment group was better than that of the control group.(4)Comparison of histopathological scores:(1)Total histopathological scores:the differences between the two groups were statistically significant(P < 0.01)when compared with the total scores before treatment.After treatment,the total score of the treatment group was lower than that of the control group,and the difference was statistically significant(P < 0.05).(2)Histopathology individual scores: after treatment,the inflammation score decreased compared with that before treatment,and the difference was statistically significant(P <0.01).There was no statistically significant difference in the comparison of intestinal metaplasia(P > 0.05).After treatment,the inflammation index score in the treatment group was lower than that in the control group,and the difference was statistically significant(P < 0.01).There was no statistically significant difference between the treatment group and the control group for Intestinal metaplasia(P > 0.05).(5)Serum indexes: PGI,PGR and G-17 values in the two groups increased to different degrees after treatment compared with those before treatment,and the differences were statistically significant(P < 0.01 or P < 0.05).There was no statistically significant difference between the PGⅡ values of the two groups(P > 0.05).After treatment,the PGI,PGR and G-17 values in the treatment group were higher than those in the control group,with statistically significant differences(P <0.01 or P < 0.05),and the treatment group was superior to the control group.There was no statistically significant difference between PGⅡ values in the treatment group and the control group(P > 0.05).Conclusion: The treatment of patients with(damp-heat syndrome)Hpassociated chronic gastritis with intestinal metaplasia with Wei Fu Kang Prescription can improve clinical symptoms,increase the eradication rate of Hp,and improve the inflammatory pathology of gastric mucosa by regulating serum PGI,PGR and G-17 levels of patients.Probably due to the small sample size and short observation time,no significant differences were shown before and after enterocolitis treatment for the time being. |
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