Study On The Effect Of Paroxetine Hydrochloride Combined With Reminiscence Therapy On Mild Behavior Impairment

Background: Mild behavioral impairment(MBI)is a transitional stage between normal aging and dementia,which may lead to increased susceptibility to various types of dementia,People with this disease are in the early stages of dementia.Therefore,the early diagnosis and treatment of MBI is of great clinical significance.However,because the basic life ability of MBI remains intact,the symptoms are often atypical,which is often ignored by patients and their families,and the optimal intervention time is missed.Various studies and clinical practice have confirmed that by comprehensively considering neuropsychiatric symptoms,neuroimaging,central nervous system biomarkers and neuropsychological tests,the onset of MBI can be detected earlier,and effective treatment measures can be taken in time,thus effectively delaying the occurrence of dementia.Paroxetine hydrochloride tablets are a selective serotonin reuptake inhibitor for a wide range of conditions,including various types of depression,obsessive-compulsive neurosis,panic disorder with or without agoraphobia,social phobia,social anxiety disorder,and can prevent the recurrence of anxiety and depression symptoms.With the increasing emphasis on the socio-psycho-biomedical model,the mental health of the elderly is also getting more and more attention.Reminiscence therapy has been proved by many domestic and foreign experts as an efficient and safe means of psychological treatment for the elderly,and its application has been gradually promoted.Studies have confirmed that reminiscence therapy can fully improve the symptoms of depression in the elderly and play a role in slowing down the cognitive decline of all kinds of dementia,help the elderly get rid of anxiety,depression and other negative emotions,improve their quality of life.Objective: To investigate the effect of paroxetine hydrochloride tablets combined with reminiscence therapy on mild behavioral impairment,and the effect on cognitive function and social function.Method: Eighty subjects who met the diagnostic criteria for mild behavioral impairment were randomly divided into control group,drug treatment group and combined treatment group,and scored on the Mild Behavioral Impairment Checklist(MBI-C),Mini-mental State Examination(MMSE)and Social Disability Screening Schedule(SDSS).The control group was given health education on mild behavioral disorder.In addition to health education,the drug treatment group was treated with paroxetine hydrochloride tablets.On the basis of receiving drug therapy and health education,the combined treatment group was treated with reminiscence therapy for 8weeks.At 8 weeks of treatment and 4 weeks after treatment,the improvement of mental symptoms of mild behavior impairment before and after treatment was compared with MBI-C score,cognitive function improvement before and after treatment was compared with MMSE score,and the improvement of social function was compared with SDSS scale before and after treatment.Results: There was no statistical difference in the general data of the three groups:control group,drug treatment group and combined control group.In terms of the improvement of MBI mental symptoms,there were statistically significant differences in the improvement of MBI-C score between the combined treatment group and the drug treatment group(p < 0.05).In terms of cognitive function improvement,there was no significant difference in MMSE score between the drug treatment group and the control group(p > 0.05),but there was significant difference in MMSE score between the combined treatment group at each time point(p < 0.05).In terms of social function,the SDSS score of drug treatment group and control group was significantly different at the 8th week of intervention compared with that before intervention(p < 0.05).There was no significant difference in SDSS score at 4 weeks after treatment compared with 8weeks after treatment(p > 0.05).The improvement of MBI-C,MMSE score and SDSS score at each time point in combination treatment group was statistically significant compared with drug treatment group and control group(p < 0.05).Conclusions: Paroxetine hydrochloride tablets combined with reminiscence therapy can effectively improve the mental behavior symptoms,cognitive function and social function of the elderly with mild behavior impairment,and the efficacy is better than Paroxetine hydrochloride tablets alone and the control group,which is worthy of in-depth and extensive research.