Analysis Of Prethrombotic State Related Indicators In Patients With Obstructive Sleep Apnea Hypopnea Syndrome

Objective: To analyze the changes of prethrombotic state related indicators in patients with Obstructive Sleep Apnea hypopnea Syndrome(OSAHS).To investigate the correlation between OSAHS and thrombotic events.To study the effect of different degrees of OSAHS on thrombotic events in patients.Methods: A total of 521 patients who underwent polysomnography(PSG)monitoring in the First Affiliated Hospital of Wannan Medical College and the Second Affiliated Hospital of Wannan Medical College from May 2021 to June 2022 were retrospectively analyzed,including 443 patients with Apnea hypopnea Index(AHI)≥5 times/hour.Seventy-eight patients with AHI < 5 times/hour were enrolled in the OSAHS observation group(AHI≥5 times/hour)and 48 patients in the control group(AHI < 5times/hour)after exclusion criteria screening.According to the AHI value,the observation group was further divided into mild OSAHS group(5≤AHI < 15),moderate OSAHS group(15≤AHI < 30),and severe OSAHS group(AHI≥30).According to the occurrence of thrombotic events,OSAHS observation group was further divided into thrombotic event group(n=50)and non-thrombotic event group(n=116).General data,medical history,pre-thrombotic status related indicators,and cardiac ultrasound related indicators were collected,and statistical methods were used for group analysis and correlation analysis.Results: 1.There were statistically significant differences in thrombotic events between mild OSAHS group,moderate OSAHS group and severe OSAHS group and the control group(P < 0.05).Correlation analysis showed that the occurrence of thrombotic events was positively correlated with the severity of OSAHS(r=6.655,P=0.010).2.To Compared with the control group,the observation group had the Lowest Oxygen Saturation(LSa O2),AHI,D-D dimer,and Left Atrial Diameter(LAD),Left Ventricular Ejection Fraction(LVEF),and the ratio of early mitral valve peak velocity E to late mitral valve peak velocity A(E/A)were statistically different(P < 0.05).There were no significant differences in white blood cell(WBC),red blood cell(RBC),platelet(PLT),hematocrit(HCT),prothrombin time(PT),thrombin time(TT),fibrinogen(FBG)and Left Ventricular Diastolic Diameter(LVIDd)between the two groups(P > 0.05).3.There were significant differences in D-D dimer,WBC,HCT,LAD,E/A and AHI between the thrombotic event group and the non-thrombotic event group(P < 0.05).There were no significant differences in LSa O2,RBC,PLT,PT,TT,FBG,LVIDd and LVEF between the two groups(P > 0.05).4.Compared with the control group,the mild,moderate and severe OSAHS groups had significant differences in LSa O2,AHI and D-D dimer(P < 0.05).Correlation analysis showed that LSa O2 was negatively correlated with the severity of OSAHS(r=-0.52,P <0.01).AHI was positively correlated with the severity of OSAHS(r=0.937,P < 0.01).D-D dimer was positively correlated with the severity of OSAHS(r=0.232,P < 0.05).Conclusion: OSAHS is one of the high risk factors for thrombotic events.The occurrence of thrombotic events is positively correlated with the severity of OSAHS.OSAHS patients,especially moderate to severe patients,have a higher risk of thrombotic events.LAD and E/A may be related to the occurrence of thrombotic events.D-D dimer and AHI may be sensitive indicators for predicting thrombotic events.