| Background and purpose of the studyIn this study,patients with advanced tumor dyspnea were given high-flow nasal cannula oxygen therapy/continuous-flow mode of(HFNC/CFM)and conventional oxygen therapy to compare the clinical efficacy and advantages of the two oxygen therapy modalities in the treatment of patients with advanced tumor dyspnea.The purpose of this study is to investigate the clinical efficacy and advantages of transnasal high-flow nasal cannula oxygen therapy in patients with advanced respiratory distress and to provide a basis for urther clinical application.Materials and MethodsThis study is a randomized controlled study.A total of 60 patients with advanced solid tumors and dyspnea were selected as the research subjects,and the subjects were randomly divided into the experimental group and the control group.On the basis of conventional anti-tumor comprehensive treatment,the experimental group was given HFNC/CFM,and the control group was given conventional oxygen therapy.The degree of dyspnea,quality of life,blood gas indexes,respiratory rate and other physiological indicators were used as evaluation indicators to observe and record the degree of dyspnea before and after treatment in both groups,and the improvement of patients’ quality of life before and after treatment:including the Self-Rating Scale of Sleep(SRSS),oral dryness and sputum viscosity.The changes in blood gas analysis values and vital signs,including heart rate(HR),respiratory rate(RR),transcutaneous oxygen saturation(SpO2)and in arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2)and acid-base value(pH),were observed and recorded for both groups before and at five time points after treatment:2 hours,6 hours,24 hours and 72 hours.The data collected were statistically analyzed using SPSS 20.0 software:measures were recorded as mean ± standard deviation(x±s),non-normally distributed measures were recorded as Median(P25-P75)and count data were recorded as N(%).The two groups of normal measures were compared between groups using the independent samples t-test and within groups before and after enrollment using the paired t-test;the two groups of non-normal measures and ordered rank data were compared between groups using the Mann-Whitney U-test analysis and within groups before and after enrollment using the Wilcoxon(W)test.Repeated measures ANOVA was performed on data measured at multiple time points.A 0.05 test level was used and a difference of P<0.05 was considered statistically significant.Result1.Comparison of the degree of dyspnea between the two groups:72 hours after treatment,patients’ Visual Analogue Scale(VAS)was lower in the test group than in the control group,and the difference was statistically significant.2.Comparison of the quality of life between the two groups:72 hours after treatment,SelfRating Scale of Sleep(SRSS),oral dryness score and sputum viscosity score were lower in the experimental group than in the control group,and the difference was statistically significant(P<0.05).3.Comparison of blood gas analysis between the two groups:2 hours after treatment,the PaCO2 experimental group was higher than the control group,and 24 hours after treatment,the PaCO2 experimental group was lower than the control group,the difference was statistically significant(P<0.05).4.Comparison of other physiological indexes between the two groups:the respiratory rate of the test group 6 hours after treatment was lower than that of the control group,and the heart rate of the test group 24 hours after treatment was lower than that of the control group,the difference was statistically significant(P<0.05).Conclusion1.Compared with conventional oxygen therapy,the use of HFNC/CFM can better relieve the degree of dyspnea of patients.2.HFNC/CFM can improve patients’ quality of life,improve their sleeping conditions,make sputum less viscous,dilute sputum for easy coughing,and provide high oral comfort,which is worthy of clinical promotion.3.From the analysis of blood gas index results,HFNC/CFM is significantly better than conventional oxygen therapy in improving oxygenation,increasing PaO2,SpO2,and reducing PaCO2 in patients with advanced tumor dyspnea.4.HFNC/CFM is more effective than ordinary oxygen inhalation in reducing HR and RR in patients with advanced tumor dyspnea.It can be seen from the above that the use of HFNC/CFM can alleviate the degree of dyspnea in patients with high comfort,improve the quality of life of patients with advanced tumor dyspnea,and has a significant effect in improving oxygenation,which is easy to be accepted by patients.It is the first-line choice of oxygen therapy for patients and has broad clinical application prospects. |
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