Clinical Efficacy Observation Of Botulinum Toxin Type A In Alleviating Scar After Thyroidectomy

Objective:To observe the clinical efficacy and safety of Botulinum Toxin Type A in alleviating scarring after thyroidectomy.Methods:According to the inclusion criteria and exclusion criteria,60 patients who underwent thyroidectomy in the Department of Breast thyroid surgery of the affiliated Hospital of Qinghai University from October 2020 to October 2021 were randomly divided into the botulinum toxin group(n = 30)and control group(n =30).the botulinum toxin group: Botulinum Toxin Type A was subcutaneously injected along both sides of the incision after thyroidectomy within 24 hours after thyroidectomy.Control group: no Botulinum Toxin Type A was injected into the incision after thyroidectomy.Both groups were followed up at 1st,3rd,and 6th month after surgery,using the VSS and VAS to assess the scar comprehensively.The incidence of adverse reactions,the total effective rate and the satisfaction of patients were recorded.Results:1.Color: the color scores of the botulinum toxin group were lower than those of the control group at the 1st and 3rd month after surgery,which was statistically significant(P<0.05),but there was no significant difference between the two groups at the 6th month after surgery(P>0.05).2.Thickness: there was no significant difference in the scar thickness score between the two groups at the 1st month after operation(P>0.05),At the 3rd and 6th month after operation,the scar thickness score in the botulinum toxin group was lower than that in the control group,and the difference was statistically significant(P<0.05).3.Vascular distribution and softness: compared between groups,the scar vascular distribution and softness scores of patients in the botulinum group were lower than those in the control group at three follow-up time points,and the difference was statistically significant(P<0.05).4.Total score of VSS: the total score of scar VSS in the 1st,3rd and 6th month after surgery in the two groups was statistically significant(P<0.05),and the total score of VSS in the botulinum toxin group was significantly lower than that in the control group.5.Pain VAS: the scar pain score in the botulinum group was significantly lower than that in the control group at 1and 3 month after surgery(P<0.05),but there was no significant difference between the two groups at the 6th month after surgery(P>0.05).6.Pruritus VAS: the score of scar pruritus in the botulinum toxin group at the 1st,3rd and 6th month after surgery were lower than that in the control group,which was statistically significant(P<0.05).7.Compared within the group,there were significant differences in the above evaluation indexes between the botulinum toxin group and the control group at three different follow-up time points(P<0.05).8.During the 6-month follow-up,the total effective rate was 83.3% in the botulinum toxin group and 50.0% in the control group,the difference was statistically significant(P<0.05).The total satisfaction rate of the botulinum toxin group was90.0%,and that of the control group was 60.0%,the difference was statistically significant(P<0.05).There were no serious adverse reactions in the two groups during the treatment and follow-up.Conclusions:1.The clinical effect of Botulinum Toxin Type A in alleviating postoperative thyroid scar is precise,with no significant adverse reaction.2.Botulinum Toxin Type A can improve the satisfaction of patients with the postoperative scar.