A Preliminary Study Of Botulinum Toxin Type A In The Prevention And Treatment Of Postoperative Thyroid Scar

Objective To investigate the clinical effect and appropriate dose of botulinum toxin type A in preventing and treating scar after traditional thyroidectomy.Methods（1）From December 2019 to January 2020,some patients undergoing traditional thyroidectomy in the Department of Otolaryngology head and Neck Surgery of our hospitalwere included in the study and randomly divided into high-dose group and low-dose group.The incisions of each patient were then randomly divided into the study side and the control side.Immediately after surgery,high-dose or low-dose botulinum toxin type A was injected into the study side of the incision of patients in the high-dose group or low-dose group,and equal volume of normal saline was injected into the control side.Scar was assessed at 6-month follow-up using the Patient-observer Scar Assessment Scale and the Vancouver Scar Assessment Scale.（2）From June 2020 to December 2020,patients with hypertrophic scar after thyroidectomy admitted to the Plastic Surgery Department of our hospitalwere injected with botulinum toxin TYPE A into the lesion.POSAS and VSS were used to evaluate the scar during 6-month follow-up.Results（1）Thirty-two patients completed the study,two groups of the side of the injection of botulinum toxin type A scar than control can improve the lateral scar in appearance,the side of scar side of scar and high dose group than control research side scar low dose group research side of scar after POSAS and VSS to evaluate statistically significant;（2）A total of 15 patients completed the study.The appearance of hypertrophic scar before injection was significantly improved compared with those 6months after injection,and the difference was statistically significant by the POSAS and VSS.Conclusion（1）Local injection of BTX-A at the incision of traditional thyroidectomy can improve the appearance of scar,improve the overall satisfaction of patients,and achieve the effect of preventing and treating hypertrophic scar.（2）Immediate postoperative injection of high-dose BTX-A is more effective than injection of low-dose BTX-A in preventing hypertrophic scar at the incision of traditional thyroidectomy.