To Investigate The Effect Of Pregnancy Timing On Pregnancy Outcome In IUI Patients

Objective To investigate the effect of IUI timing on pregnancy outcome after first intrauterine artificial insemination(IUI)failure and endoscopic endometrial polyposectomy.Also explore whether ovulation therapy and the effect of insemination in the same cycle on pregnancy outcome.Methods A retrospective study protocol was designed to collect patients with failed IUI in our hospital from May 2017 and subsequent IUI in December 2021,totaling 120 couples for 266 cycles.According to the timing of IUI after endoscopic endometrial polypectomy,all the study subjects were divided into three groups:1 to 3 postoperative menstrual cycle groups,4 to 6 postoperative menstrual cycle groups,and 7 to 12 postoperative menstrual cycle groups.Clinical pregnancy in the three groups.All enrolled patients were divided into natural cycle groups and ovulation induction cycle groups according to whether to treat ovulation induction,and the clinical pregnancy rates of the two groups were analyzed and compared.And according to the number of insemination in the same cycle,all the patients were divided into single and double insemination group to analyze and compare the clinical pregnancy rate of the two groups.Results1.The clinical pregnancy rate of 1 to 3 postoperative menstrual cycles and 4 to 6 postoperative menstrual cycles were higher than that of 7 to 12 postoperative menstrual cycles,respectively,and the difference was statistically significant(P<0.05).2.There was no significant difference between the clinical pregnancy rate of 1 to 3 postoperative menstrual cycles and 4 to 6 postoperative menstrual cycles(P>0.05).3.The clinical pregnancy rate of the ovulatory cycle group(21.8%)was higher than that of the natural cycle group(11.8%),and the difference was statistically significant(P<0.05).4.The clinical pregnancy rate in the double insemination group in the same cycle(19.8%)was higher than that in the single insemination group(16.7%),but the difference was not significant(P>0.05).Conclusion For patients with failed first IUI,IUI after endoscopic endometrial polypectomy should consider the specific timing of pregnancy.IUI for 4 to 6 menstrual cycles is better compared to IUI after 7 to 12 menstrual cycles.ovulation cycle treatment and double insemination in the same cycle may improve pregnancy outcomes.Therefore,early IUI for pregnancy aid,rational use of ovulation-stimulating cycle and improving the number of insemination in the same cycle may improve the clinical pregnancy rate.Therefore,various factors should be considered comprehensively in the follow-up practice to develop the most reasonable pregnancy aid plan.