A Cross-sectional And Longitudinal Study Of Metabolic Components And Body Composition In Patients With Major Depressive Disorder

Objective Observe the body composition differences between patients with first-episode major depressive disorder(FE-MDD),recurrent major depressive disorder(RMDD)and healthy controls(HC)through bioelectrical impedance analysis,and explore the characteristics of body composition of patients with major depressive disorder(MDD).Methods In this study,240 outpatients diagnosed with MDD were collected and divided into first-onset depressive disorder(n=120)and recurrent depressive disorder(n=120)according to whether they had their first attack and their medication status;healthy volunteers were selected as the control group(n =120).Collect general information and use a body composition analyzer to measure body composition.Results The phase angle of HC is significantly higher than that of FE-MDD and RMDD;the body mass index,body fat percentage,visceral fat area and waist circumference of RMDD are significantly higher than that of FE-MDD and HC.Regression analysis among the three groups showed that the phase angle(OR= 0.428,95% Cl:0.211~0.869)was the protective factor for depression,and the visceral fat area(OR=1.03,95% Cl: 1.009~1.052)was the risk of depression Factors(p<0.05).Conclusion Compared with HC,the body composition of FE-MDD and RMDD will have a certain degree of change,and the visceral fat area and phase angle may be one of the influencing factors of MDD.Therefore,clinically,early body composition monitoring should be carried out for patients with depression.Intervention provides an important basis.Objective To longitudinally observe the changes of metabolic components and body composition in patients with first-episode major depressive disorder(FE-MDD),and the effects of different types of drugs on metabolic components and body composition.To explore the characteristics of body composition in patients with MDD as the disease progresses.Methods This study collected 98 outpatients diagnosed with major depressive disorder(MDD)who had a first episode,and had never used antidepressants,antipsychotics and other psychiatric drugs,and had previously used transcranial magnetic stimulation.and other physical therapy.General data collection,clinical scale evaluation,diet and exercise records,metabolic components,and body composition were collected.Results(1)TG,waist circumference,body weight,BMI,PBF and VAF at 24 weeks of FE-MDD patients were significantly higher than baseline,and HDL-c at 24 weeks was significantly lower than baseline.(2)The TG and waist circumference of FE-MDD patients in the antidepressant alone group and the combined antipsychotic drug group were significantly higher than the baseline at 24 weeks,and the HDL-c at24 weeks was significantly lower than the baseline.(3)The BMI,PBF and VFA of FE-MDD patients in the antidepressant alone group and the combined antipsychotic drug group were significantly higher than the baseline at 24 weeks,and the baseline Min in the antidepressant alone group was significantly higher than that at 6 weeks.(4)Waist circumference,BMI,PBF,and VFA in the combined antipsychotic drug group at 24 weeks were significantly higher than those in the single antidepressant drug group.Conclusion FE-MDD patients have a certain degree of changes in metabolic components and body composition at 24 weeks,and antidepressant and antipsychotic drugs have certain effects on metabolic components and body composition,especially olanzapine-based drugs.Second-generation antipsychotic drugs.Therefore,early body composition monitoring should be performed in patients with FE-MDD to provide an important basis for early intervention.