Prediction Of Postoperative Mortality Risk Of Colon Cancer By Centrosome Amplification

Objective:To evaluate whether there are differences in the degree of centrosome expansion in colon cancer tissues of patients with different survival outcomes,and further explore the predictive significance of the percentage of centrosome amplification cells(CA%)on the risk of postoperative death of colon cancer.Methods:A retrospective study was conducted with the 5-year survival rate(OS)of patients with colon cancer as the end point.Immunofluorescence staining(IF)was used to detect the percentage of centrosome amplification cells(CA%)in colon cancer tissues of surviving patients(n = 40)and dead patients(n = 20).Kaplan Meier survival curve was drawn and Log-Rank test was used to compare the OS between low-risk group and high-risk group.Univariate and multivariate Cox regression analysis was used to evaluate whether CA% is an independent predictor of postoperative death risk of colon cancer,and to further explore its prognostic significance.Results:The level of CA% in colon cancer tissue in postoperative death group was significantly higher than that in postoperative survival group(P < 0.05).Compared with Kaplan Meier survival curve and log rank test,OS in high CA% group was significantly lower than that in low CA% group(P < 0.05).According to the results of univariate and multivariate Cox regression analysis,CA% can be used as an independent predictor of the risk of postoperative death of colon cancer(P < 0.05).Conclusion:CA% in colon cancer tissue of patients with colon cancer in the death group was significantly higher than that in the survival group.CA% is an independent predictor of postoperative death risk of colon cancer,which has certain clinical significance for the prognosis of colon cancer.