Clinical Study On Mental Health Status And Quality Of Life Of Patients With Laryngopharyngeal Reflux Disease

Objective: To study the mental health status and quality of life of the patients with laryngopharyngeal reflux disease(LPRD),and to explore the correlation of clinical symptoms and signs,mental health status and quality of life of LPRD patients.In order to provide reference for the evaluation of mental health status and quality of life of LPRD patients,and provide new ideas for clinical treatment of LPRD patients.Methods: From May 2021 to January 2022,patients with pharyngeal foreign body sensation,persistent throat clearing,dry pharyngeal pain and other pharyngeal discomfort symptoms with the course of disease ≥ 3 months were selected as the subjects.The RSI and RFS were evaluated,and the RSI ≤ 13 and RFS ≤ 7 were included in the non-LPRD group;Patients with RSI > 13 and/or RFS > 7 were regarded as suspected LPRD,and patients who responded to diagnostic treatment with PPI after 8 weeks were included in LPRD group.At the same time,the healthy volunteers from the physical examination center of a people’s hospital were included in the healthy control group.HADS and SF-36 Health Survey Scale scores were performed in non-LPRD group and healthy control group.RSI score,RFS score,HADS score and SF-36 health Survey scale score were performed in LPRD group before and after treatment.Results:1.Comparison of HADS-A and HADS-D scores among LPRD group before treatment,healthy control group and non-LPRD group.The score of LPRD group before treatment was higher than that of healthy control group and non-LPRD group(P <0.05).Comparison of HADS-A and HADS-D scores among LPRD group after treatment,healthy control group and non-LPRD group.The score of LPRD group after treatment was higher than that of healthy control group and non-LPRD group(P< 0.05).2.Comparison of RSI score,RFS score,HADS-A and HADS-D score before and after treatment in LPRD group.The scores before treatment were higher than after treatment(P < 0.05).3.Comparison of SF-36 scores in LPRD group before treatment,healthy control group and non-LPRD group.There was no difference in PF score among the three groups(P > 0.05).In the other seven dimensions,the scores of LPRD group before treatment were lower than those of healthy control group and non-LPRD group(P <0.05).Comparison of SF-36 scores in LPRD group after treatment,healthy control group and non-LPRD group.There was no difference in PF score among the three groups(P > 0.05).In the other seven dimensions,the scores of LPRD group after treatment were lower than those of healthy control group and non-LPRD group(P <0.05).4.Comparison of SF-36 scores of LPRD patients before and after treatment.There was no difference in PF score(P > 0.05).The scores of the other 7 dimensions were lower before treatment than after treatment(P < 0.05).5.RSI scores of LPRD patients before treatment were positively correlated with HADS-A and HADS-D scores(r =0.81,P < 0.05;r =0.784,P < 0.05);RFS score was positively correlated with HADS-A and HADS-D score(r =0.668,P< 0.05;r =0.663,P < 0.05).6.The RSI score of LPRD patients before treatment was not significantly correlated with the physiological function PF score(r =-0.045,P =0.751),but was negatively correlated with the other seven dimensions(P < 0.05).RFS score before treatment had no significant correlation with physiological function PF score(r =0.006,P=0.964),and was negatively correlated with other 7 dimensions(P < 0.05).7.HADS-A score of LPRD patients before treatment was not significantly correlated with physiological function PF score(r =-0.074,P =0.598),but was negatively correlated with other 7 dimensions(P < 0.05).There was no significant correlation between HADS-D score and physiological function PF score(r =0.000,P =0.999).It was negatively correlated with the scores of other 7 dimensions(P < 0.05).Conclusion: LPRD patients are prone to anxiety,depression and low quality of life,their symptoms and signs are negative correlation with both mental health status and quality of life,the more severe the symptoms and signs are,the more likely they are to have anxiety,depression and low quality of life.Attention to the mental health status and quality of life of patients in the treatment of the disease is conducive to the choice of treatment and improve the therapeutic effect.