| Objective: By comparing and observing the clinical efficacy of selfmade Runchang Jianpi decoction combined with biofeedback and biofeedback in the treatment of pelvic floor relaxation constipation,and to verify the clinical effectiveness of self-made Runchang Jianpi decoction combined with biofeedback.By using relevant technical methods of network pharmacology,its molecular mechanism was analyzed.To provide an innovative,safe and feasible conservative treatment method for clinical treatment of pelvic floor relaxation constipation.Methods: 60 patients who met the inclusion criteria were randomly divided into observation group(n = 30)and control group(n = 30).The patients in the observation group were treated with self-made Runchang Jianpi decoction combined with biofeedback,while the patients in the control group were treated with biofeedback only.The difference of clinical symptom score and rectoanal pressure of constipation between the two groups before and after treatment and during follow-up were observed and statistically analyzed to compare the difference of clinical efficacy between the two groups.The main chemical components,action targets and disease-related targets of the self-made Runchang Jianpi decoction were excavated through the network database and related literature,and the protein-protein interaction analysis and network construction were carried out,and the enrichment analysis and KEGG pathway analysis were carried out,and then the target-pathway network was constructed.results: 1.After treatment,the improvement rate of the observation group was 40.0%,and the effective rate was 60.0%,while that of the control group was 70.0%,and the effective rate was 13.3%.The difference was statistically significant(P < 0.05).2.The scores of constipation symptoms in the two groups after treatment were significantly lower than those before treatment(P < 0.05),and the scores of defecation difficulty,defecation frequency per week,incomplete defecation and fecal traits in the observation group were significantly lower than those in the control group(P < 0.05).There was no significant difference in the score of anal drop sensation between the two groups after treatment(P > 0.05).There was no significant difference in symptom scores between the two groups after treatment(P > 0.05).3.The anal resting pressure,maximum systolic blood pressure and maximum tolerance threshold of the two groups after treatment were significantly higher than those before treatment,and the initial sensory threshold decreased significantly after treatment(P <0.05).There was no significant difference between the two groups(P >0.05).4.In the course of this trial,there were no shedding cases and excluded cases,the patients were well tolerated during the treatment,and no adverse reactions occurred in the two groups.After treatment,no abnormalities were found in blood routine,urine routine,stool routine,liver and kidney function,ECG and so on.5.The core active components of self-made Runchang Jianpi decoction are stigmasterol,quercetin,luteolin,β-sitosterol,arachidonic acid,etc.;the core targets are IL6,IL1 B,TNF,etc.;the pathway is mainly related to IL-17 signal pathway,NF-kappa B signal pathway and so on.conclusion: 1.Self-made Runchang Jianpi decoction combined with biofeedback and simple biofeedback has a certain therapeutic effect on pelvic floor relaxation constipation and can improve patients’ clinical symptoms and rectoanal function.2.The curative effect of self-made Runchang Jianpi decoction combined with biofeedback is better than that of biofeedback alone.Self-made Runchang Jianpi decoction combined with biofeedback is safe and effective in the treatment of pelvic floor relaxation constipation and can be further promoted in clinic.4.Through the network pharmacological analysis,it is found that the self-made Runchang Jianpi decoction plays a therapeutic role through multiple ingredients,multiple targets and multiple pathways,which provides a certain theoretical basis for its clinical application and research. |
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