Correlation Analysis Between Non-alcoholic Fatty Liver Disease And Early Renal Dysfunction In Different Genders

Objective The aim of this study was to investigate whether non-alcoholic fatty liver disease(NAFLD)showed a significant correlation with early renal dysfunction in different genders,so as to provide clinical evidence for the formulation of new strategies for prevention and treatment of NAFLD and chronic kidney disease(CKD).Methods Based on the inclusion and exclusion criteria,a total of 1767 valid samples were obtained from the people who underwent physical examination in the Affiliated Hospital of Yanbian University from January to December 2020.After collected demographic and clinical characteristics,subjects were divided into male group(n=1005)and female group(n=762)according to gender.And then according to the estimated glomerular filtration rate(e GFR),the two groups were separately divided into two subgroups:low renal function group(e GFR<90ml/(min·1.73m~2))and normal renal function group(e GFR≥90ml/(min·1.73m~2)).All statistical analyses were performed in SPSS,version24.The correlation analysis was made by linear or rank correlation,and logistic regression analysis was used to analyze the risk of low GFR with NAFLD,high TG,high SUA and low GFR in different gender and different models.Results1.The correlation between e GFR and other indicators in different genders showed that e GFR in the male group was negatively correlated with some variables such as Age,TBIL,DBIL,PA,BUN,CREA,SUA,Cys-C,TC/HDL and FIB-4,while positively correlated with others such as FBG,HDL,GGT,CHE,P and PLT,and that e GFR in the female group was negatively correlated with some variables such as Age,SBP,DBP,TC,TG,LDL,AST,ALT,GGT,CHE,TBIL,DBIL,PA,BUN,CREA,SUA,CO2-CP,Ca,Cys-C,TC/HDL and FIB-4,while positively correlated with others such as HDL,ALB,ALB/GLB and PLT.2.In the male group,NAFLD and high TG were not associated with the risk of low GFR.In the female group,the risk of low GFR in the NAFLD group and the high TG group was respectively 3.595times(95%CI:1.852-6.977)and 2.917 times(95%CI:1.552-5.482)higher than that in its own normal group without adjusting for confounders,while the risk disappeared after adjusting for confounders such as Age,TG,and NAFLD.In the male group,the risk of low GFR in the high SUA group was 1.553times higher than that in the control group(95%CI:1.148-2.045)without adjusting for confounders(95%CI:1.148-2.045),while 1.689 times higher than the latter(95%CI:1.234-2.313)after adjusting for confounders such as Age,AST,and CYS-C.In the female group,the risk of low GFR in the high SUA group was 7.786 times higher than that in the normal group without adjusting for confounders(95%CI:4.139-14.645),while 4.160 times higher than the latter after adjusting the confounders such as Age,TG and NAFLD(95%CI:1.946-8.893).3.In the male group,there was no interaction in the risk of low GFR with NAFLD and TG group and NAFLD and SUA group.The interactions were observed in the female group,in which the risk of low GFR in the group of NAFLD and high TG was 3.963 times higher than that in its normal group(95%CI:1.951-7.049),and the risk in the group of NAFLD and high SUA was 8.013 times higher than that in its normal group(95%CI:2.746-23.384).Conclusions1.NAFLD and high TG are associated with low GFR in women,but not in men..2.High SUA is a risk factor for low GFR..3.The risk of low GFR is increased in the NAFLD and high TG compared with the normal TG without NAFLD in women.Similarly,such high risk also exists in the NAFLD and high SUA compared with the normal SUA without NAFLD in women.However,NAFLD and TG,NAFLD and SUA did not increase the risk of low GFR in men.