Correlation Analysis On Nonalcoholic Simple Fatty Liver And Estimated Glomerular Filtration Rate

Objective:To analyze the relationship between nonalcoholic simple fatty liver (NAFL) and estimated glomerular filtration rate (eGFR), further to investigate the effects of NAFLD on renal function.Methods:To collect 881 cases from January to June in 2014 in the First Affiliated Hospital, College of Medicine, Zhejiang University, detect glutamyl transpeptidase (GGT), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FPG), uric acid (UA) and hepatic ultrasound, measure the height, weight, waist circumference (WC), systolic blood pressure (SBP) and diastolic blood pressure (DBP), and count body mass index (BMT) and eGFR.Results:In the 881 cases, NAFL was 274 (212 males,62 females, mean age for 48.0 ± 7.3 years). Healthy population was 607 (321males,286 females, mean age for 47.7 ± 8.8 years). There were significant differences between the two groups in terms of gender, SBP, DBP, UA, GGT, TG, TC, HDL-c, LDL-c, FPG, WC, BMI and eGFR levels (all P <0.05). The mean eGFR level of NAFL was lower than the one of healthy population (107.5 ± 20.0 mL/min/1.73m2 vs.112.8 ± 24.6 mL/min/1.73m2). The study population was divided into four groups based on eGFR level from low to high, the prevalence of NAFL was a corresponding decline(Ptrend= 0.019). After age and gender correction, Spearman correlation analysis showed that eGFR was negatively correlated with NAFLD-related risk factors such as DBP, WC, BMI, GGT, TG, TC, LDL-c and UA (all P<0.05).Conclusion:eGFR is closely related with NAFL and its related factors, and NAFL can influence eGFR , NAFLD is one of risk factors resulting in the decline of eGFR.