Expression Of VEGF And B-FGF2 In Different Pathological Types Of Benign Prostatic Hyperplasia And Its Clinical Significance

Objective: Benign prostatic hyperplasia(BPH)seriously affects the health of middle-aged and elderly men all over the world.With the improvement of human life quality and average life expectancy,among urological diseases,prostate lesions,especially BPH,have an obvious increasing trend.However,the pathogenesis of benign prostatic hyperplasia remains unclear.For a long time,the medical community has conducted a lot of research on the etiology of benign prostatic hyperplasia,but so far the etiology of BPH has not been fully understood and confirmed.In this experiment,the expression of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(b-FGF2)related to cell proliferation in different pathological types of benign prostatic hyperplasia were investigated,for further study.Research on the pathogenesis,diagnosis,and treatment of benign prostatic hyperplasia provides a better way.Methods: In this experiment,immunohistochemical method(SP method)was used for research,and a total of 82 cases of benign prostatic hyperplasia tissue paraffin specimens were detected,which were divided into 2 groups according to the pathological type,of which 1 group was benign prostatic hyperplasia mainly with interstitial hyperplasia There were 41 tissue paraffin specimens,and the other group was 41 tissue paraffin specimens of benign prostatic hyperplasia mainly with glandular hyperplasia.The expressions of two different cell growth factors,VEGF and b-FGF2,in different pathological types of benign prostatic hyperplasia were detected.,and then provide a certain basis for further confirming the pathogenesis of benign prostatic hyperplasia and providing a new treatment plan in the future clinical treatment.We used SPSS 24.0 to further analyze all the data obtained in the experiment.We used Graph Pad Prism 8 to draw the graphs,and the χ2 test was used to analyze the count data.When the P value was less than 0.05,we considered the difference to be statistically significant.Results: 1.The positive expression of b-FGF2 in benign prostatic hyperplasia(BPH)was 88%(36/41),which was higher than that in benign prostatic hyperplasia(BPH)17%(7/41).The immunohistochemical results were statistically significant(P < 0.05).The expression of basic fibroblast growth factor b-FGF2 in BPH was significantly higer than that in BPH.2.The positive expression of VEGF was 93%(38/41)in benign prostatic hyperplasia(BPH)and 85%(35/41)in benign prostatic hyperplasia(BPH).Vascular endothelial growth factor(VEGF)is strongly expressed in different pathological types of benign prostatic hyperplasia(BPH).3.Through collecting relevant case information and follow-up investigation of patients,it was found that about 76%(31/41)of the patients had urinary retention in the pathological types of benign prostatic hyperplasia mainly caused by interstitial hyperplasia,and about12%(5/41)of the patients had urinary retention in the pathological types of benign prostatic hyperplasia mainly caused by glandular hyperplasia.The results of the two were statistically significant(P < 0.05),much higher than those of the patients with benign prostatic hyperplasia mainly caused by glandular hyperplasia.Conclusion: The expression of basic fibroblast growth factor b-FGF2 in patients with interstitial hyperplasia BPH was significantly higher than that in patients with gland hyperplasia BPH.It is suggested that b-FGF2 plays an important role in benign prostatic hyperplasia,which has further clinical significance for studying its pathogenesis and subdividing the pathological types of benign prostatic hyperplasia,and provides theoretical support evidence for its further treatment.2.Vascular endothelial growth factor(VEGF)is strongly expressed in different pathological types of benign prostatic hyperplasia(BPH),which confirms that VEGF plays an important role in the etiology of BPH and provides a new direction for the etiology and treatment of BPH.3.The incidence of urinary retention is higher in patients with benign prostatic hyperplasia(BPH),the degree of obstruction is more serious,and the probability of surgery is higher.