Prognostic Effects Of Sublobectomy And Lobectomy On Patients With Stage IA1 Non-Small Cell Lung Cancer

Objective: Lung cancer is the leading cause of cancer-related mortality worldwide.Recent studies have shown that partial pulmonary resection(segmentectomy,Wedge resection)may be an alternative to lobectomy for surgical treatment of non-small cell lung cancer(NSCLC),which is less than 1 cm.while age,gender,pathology,histological grade and lymph node dissection may also affect the prognosis of patients.The purpose of this study was to compare the lung lobectomy and partial pulmonary resection for patients with stage T1a(> 0 to < 10 mm)of non-small cell lung cancer(NSCLC)according to the eighth edition of the AJCC TNM system.Will the number of lymph node dissection groups and the biological indicators of patients were analyzed,such as age,sex,pathology,histological grade and tumor location effect of survival rate.Methods: We identified 743 patients with stage IA1 non-small cell lung cancer from the SEER database.Chi-square test,Cox proportional hazard model and K-M survival curve are used to analyze the biological information of all patients,evaluating the impact of these factors on non-small cell lung cancer.Result: There are 743 patients,136(18.3%)underwent wedge resection,34(4.6%)underwent segmentectomy and 573(77.1%)underwent lobectomy.There were significant differences in age,pathological type and lymph node dissection group among patients with different surgical methods.The prognostic factors of NSCLC were age and histological differentiation.Among them,age > 70(HR = 1.72,95% CI: 1.101-2.688),moderate differentiation(HR = 2.756,95% CI: 1.605-4.734)and low differentiation(HR= 2.968,95% CI: 1.658-5.313),while there was no significant difference in the surgical method,number of lymph node dissection groups,gender,pathology and location of tumors.There were no significant differences in the prognosis of the patients in age,sex,pathological type,lymph node dissection group and tumor location.While standard lobectomy has a better prognosis than sublobectomy when the tumor is low-differentiation in histological.Conclusion: The age of diagnosis and the degree of differentiation of tumors affect the survival of patients,but the surgical method number of lymph node dissection groups,gender,pathology and location of tumor have no effect on the prognosis of patients with stage IA1 non-small cell lung cancer.So limited resection may be more suitable for the treatment of small tumors because it may have fewer complications and will get better recovery of pulmonary function after surgery.