Amine compounds are very important organic compounds,which play an important role in the construction of complex nitrogen heterocyclic compounds.Many catalytic systems have been reported for the hydroamination reactions of activated alkenes such as aryl alkenes,and the reactivity has been successful in both precious and cheap metal catalysts.However,there are few reports on unactivated alkenes.Among these reactions,the hydroamination of unactivated alkenes has some shortcomings,such as harsh reaction conditions,low reactivity,cumbersome post-treatment,poor regioselective and fewer substrate scope.Therefore,the exploration of simple,efficient,economical and feasible hydroamination reaction has become the focus of research.The Aromatic amines compounds were synthesized by the hydroamination reaction of unactivated alkenes with 8-aminoquinoline as the directing group nickelcatalyzed without ligand.This method has been successfully applied to the synthesis of oxaprazine and indomethacin derivatives.At first,aldehydes(or ketones)products and alcohols products were obtained through optimization of the conditions for hydroamination,especially through the adjustion of bases,and the yield reached 88%with regioselectivity of > 99:1.Developed 51 substrates,the reactivity up to 97%,has excellent regio-and chemoselectivity.It is found that the directing group and base control the regio-and chemoselectivity for hydroamination. |