Preparation Of Small Molecule Amino Acid Aggregates And Solvent Enhancement Of Drugs

As the basic unit of protein,natural amino acids can pass through the digestive barrier and directly participate in human life activities through intragastric administration.Natural amino acids themselves are highly biocompatible.In order to make full use of this property of amino acids and further explore the potential functions of small amino acids,this paper,based on the basic physical and chemical properties of small amino acids,conducted an indepth study on the preparation conditions and practical applications of small amino acid aggregates:In an inert atmosphere,the amino acid is "melt-quenching" treatment,small molecule amino acid powder is heated to the glass transition temperature,through the precise control of the heating and cooling rate,before reaching the decomposition temperature of amino acid crystals,melting into a supercooled liquid,which can realize the characteristics of high temperature adhesion and low temperature curing,and use its viscosity to make biological adhesive.In the spatial arrangement,the glass state of small amino acid molecules presented short-range order and long-range disorder,and macroscopically,showed a high viscosity adhesive state.Because of the inherent biocompatibility of small molecular amino acids,it is possible to try to use them as biogels.It overcomes the shortcomings of adding curing agent,applying curing pressure and long curing time for the previous synthetic polymer adhesives,and can be used in more different scenarios.The hydrophobicity and low oral availability of natural antioxidants remain major challenges for widespread use.Small amino acids and hydrophobic drugs were mixed with water and heated,and the amino acid aggregates were transformed into drug carriers by utilizing the hydrogen bonding between amino acids and water molecules as well as the hydrophobic interaction between amino acid side chains and drugs.The amino acid-drugwater co-assembled oral dosage forms were constructed by using intermolecular interaction.The drug carrier can increase the solubility of hydrophobic drugs significantly,and retain its safety,no biological toxic side effects,good biocompatibility and many other advantages,improve the bioavailability of hydrophobic drugs,to provide a feasible solution to the problem of oral administration of hydrophobic drugs,and initially open up the field of biological application of small molecule amino acid aggregates.