Preparation And Properties Of Zein Gated Mesoporous Silica Sustained Release Bacteriostatic Material

At present,food safety issues are directly related to human health and life safety,and food safety has become a global focus.Strengthening the supervision and management of food safety is of great significance for ensuring public health,maintaining social stability,and promoting economic development.Although essential oils have strong antibacterial activity,there are still some limitations in their practical applications.The volatility and instability of essential oils have brought many difficulties to the application of essential oil antibacterial agents.Therefore,this article studied the preparation and properties of Zein-Functionalized MCM-41 Silica Nanoparticles with Enzyme-Responsive for Controlled Release antibacterial materials,providing new ideas and new methods for the development of new and efficient antibacterial materials,which is of great significance for promoting scientific research and technological application in related fields.In this material,a novel material with long-lasting antibacterial activity and gated antibacterial functions was prepared by combining zein with mesoporous silica,which improved the antibacterial performance and application prospects.This research has innovation and practical application value,and is of great significance for the study of sterilization field.This topic mainly studies the following aspects:Firstly,the preparation and antibacterial properties of long-lasting antibacterial materials functionalized with capsaicin-modified mesoporous silica（amino-functionalized MCM-41）are introduced.Amino-functionalized mesoporous silica（NH₂/M41）was prepared by co-condensation method,and the antibacterial properties of capsaicin,turmeric,nerol and nobiletin were compared.The results showed that capsaicin had the best antibacterial activity,with minimum bactericidal concentrations of 1-2mg/m L and 2-4 mg/m L for Escherichia coli（E.coli）and Staphylococcus aureus（S.aureus）,respectively.Capsaicin-modified antibacterial materials（CAP@NH₂/M41）were prepared by encapsulation technology to achieve antibacterial function.The experimental results showed that the prepared antibacterial materials had good antibacterial properties and could be used in medical,food and other fields.Secondly,the preparation and performance of zein-gated CAP@NH₂/M41 long-lasting antibacterial materials were studied.In terms of research methods,this chapter first prepared zein-gated CAP@NH₂/M41 long-lasting antibacterial materials（CAP@Zein/M41）and characterized them by scanning electron microscopy（SEM）,Fourier transform infrared spectroscopy（FT-IR）,thermogravimetric analysis（TGA）and N₂ adsorption-desorption.Then,the antibacterial effect and long-lasting and controlled-release effects were compared and studied.Subsequently,CAP@Zein/M41 was applied to sterilize coconut water,and its performance was studied.The study found that the material had a good inhibitory effect on E.coli and S.aureus,and could achieve controlled-release effect,prolonging the duration of antibacterial action and improving antibacterial accuracy.In addition,the material had good biocompatibility and would not cause adverse effects on organisms.The experimental results showed that the introduction of zein as an enzyme-responsive gated material improved the antibacterial performance of the material and had good control-release performance,effectively prolonging the duration of antibacterial agents.This material can be used as an efficient antibacterial material.Thirdly,the application of CAP@Zein/M41 in sterilizing coconut water was studied.The experimental results showed that this material has a good inhibitory effect on bacteria in coconut water and can effectively kill bacteria,with broad application prospects.In addition,by measuring the physical and chemical indicators such as p H value,soluble solids content,conductivity,titratable acidity,and color value,it was confirmed that the gated antibacterial material largely maintains the original quality of the food,avoiding potential harm to human health,which is of great significance for promoting scientific research and technological applications in related fields.The use of essential oil-functionalized antibacterial materials for filtering and sterilizing juice drinks has strong adjustability.Different types of essential oils have different antibacterial effects and aroma characteristics,and different types and amounts of essential oils can be selected according to the needs of juice drinks to adjust the taste and aroma of the drinks.Moreover,essential oil antibacterial agents do not leave harmful substances in the environment and do not have negative effects on the environment,showing good environmental friendliness.Based on effectively extending the shelf life of juice drinks,it can also prevent the reproduction of microorganisms in the juice,thus maintaining the fresh taste and quality of the drinks.In conclusion,this main contribution is the successful preparation of Zein-Functionalized MCM-41 Silica Nanoparticles with Enzyme-Responsive for Controlled Release（CAP@Zein/M41）,and the exploration of its application in sterilizing coconut water.In addition,through a comparative study of the antibacterial properties of essential oils,it was found that capsaicin has a good inhibitory effect on bacteria,which is of great significance for the sterilization in the food industry.The research results also provide new ideas and methods for the development of food sterilization technology.The future prospects of gated antibacterial agents are very broad.In the current antibacterial drugs,resistance has become a serious problem.However,some gated antibacterial agents can act on bacterial cell wall synthesis enzymes,and their mechanism is different from that of traditional antibacterial drugs,which can effectively prevent bacteria from developing resistance.At the same time,gated antibacterial agents have high selectivity and safety,so they have broad application prospects.Although they are still in the research stage,with the continuous progress of technology and in-depth research,gated antibacterial agents are expected to become a very effective antibacterial drug.