Study Of Two Drug Controlled Release Systems Of Mesoporous Silica And Superhydrophobic Antibacterial Biofilm

With the development of pharmacology,biomaterials and clinical medicine,carriers that can control drug release have become an increasingly important drug delivery system.Compared with the traditional mode,the drug control system has the advantages of drug targeting and sustained release in the body,effectively reducing the risk of physical discomfort caused by a large amount of drug release in a short period of time.The drug carrier is the focus of drug controlled release technology,including the biocompatibility,degradability and drug carrying capacity of the material.Therefore,it is a great significance that research on these materials to control drug release.The paper studied two drug-loaded materials separately.Pentahydroxymethylfurfural(5-hydroxymethyl-2-furaldehyde,5-HMF)has been extensively studied for its anti-oxidation and anti-inflammatory properties.However,due to its molecular structure containing aldehyde groups,it causes biological toxicity when used in excess,and its chemical instability makes it have difficulty to take a step in medicine.In order to overcome this obstacle,the paper uses a new three-dimensional dendritic mesoporous silica(3D-MSNs)as a drug carrier,which is slowly released by the degradation of the carrier,which reduces the biotoxicity of the drug and extended the efficacy of the drug.The carrier having a smaller particle size is obtained by adjusting the process.Mesoporous silica has good cytocompatibility,and enhances the stability of the hydrophilic small molecule drug that character is very active.Iodine is a broad-spectrum drug that is one of the essential trace elements in the human body.It is bactericidal and bacteriostatic effect and widely used in medicine,fuel,photographic materials and chemical reagents.What`s more,iodine is usually used to inhibit the growth of bacteria in trauma or post-operative wounds.However,due to the volatility of iodine and toxicity caused by the high concentration of iodine,iodine has the suppression of the promotion in the medical field.We synthesized a iodine-loaded superhydrophobic biofilm using a novel and easy-operating method using polytetrafluoroethylene(PTFE)and povidone(PVP).Because the surface of the superhydrophobic material is very rough,the air traps the groove in the surface of the superhydrophobic film to form an air layer.The presence of this air film makes the superhydrophobic interface a carrier for drug controlled release.Through a series of experiments,proving the biofilm has good biocompatibility,anti-adhesio,anti-bacterial effect and long-lasting antibacterial.In summary,the development of drug-controlled release carriers provides a goodapproach and far-reaching impact on the use of some drugs with poor stability and biocompatibility.