Interfacial Modification Of MXene And Its Photothermal Antibacterial Application

As is well known,bacteria are widely distributed in natural environments,and many bacteria still have strong adaptability to survive in harsh environments.Many bacteria are the cause of diseases,making the treatment of bacterial diseases an inevitable problem for humans.Antibiotics have shown amazing antibacterial effects since their discovery.However,due to the uncontrolled use of antibiotics in the early stages,many bacteria have developed resistance to drugs,Nowadays,it has become a problem that is difficult to solve and can threaten people’s health at any time.It is a problem that the world must seriously face today.The emergence of drug resistance makes the treatment of some infectious diseases more difficult,and even improper medication can worsen the condition.Therefore,we urgently need to develop new antibacterial drugs and strategies to cope with bacteria that have already developed resistance.MXene material is one of the materials widely used in the field of two-dimensional nanomaterials.Its two-dimensional layered structure gives it a large surface area,elemental composition,and unique structure,which gives it excellent photothermal and optoelectronic properties.It has high biocompatibility,and the rich reaction sites increase the possibility of surface modification and expansion processing,making it highly promising in various fields such as biomedicine.This article explores the antibacterial properties of MXene materials through photothermal properties under near-infrared light irradiation,explores new composite antibacterial agents,modifies or improves MXene,and evaluates its antibacterial properties.The research content of this paper is as follows:（1）Using Mo2Ga2C as the precursor of MAX to prepare two-dimensional nanosheets of Mo2CTx,the etching ability of hydrochloric acid is significantly weaker than that of hydrofluoric acid,making the adjustment of etching time and temperature particularly important.BODIPY with nitro group was synthesized by using 4-（2,5-Dimethyl-pyrrol-1-yl）-phenylamine and p-Nitrobenzaldehyde,and then the nitro group was reduced to an amino group to obtain an amino peroxide BODIPY（boron-dipyrromethene）.Finally,BODIPY-MXene nanosheets were prepared through the electrostatic interaction between MXene and BODIPY protonated positive charge BODIPY.The photothermal performance of the sample was tested using an MDL-Ⅲ(808 nm,1.5 W·cm^-2)laser light source.Through analysis and calculation of the data,the photothermal conversion rate was 42.6%.At the same time,the photodynamic ability of the sample was tested and it was found that its photocatalytic ability to produce singlet oxygen was somewhat improved compared to BODIPY.First,the sample was subjected to photothermal sterilization through suspension co culture.Using a dilution plate,the Photothermal sterilization activity of BODIPY-MXene against Staphylococcus aureus and Escherichia coli was determined.The results obtained showed that Mo₂CT_xalone had a good photothermal antibacterial activity,and the antibacterial activity of both reached 100%at a concentration of 100μg·m L^-1,and at a relatively low concentration gradient of 75μg·m L^-1Compared with the modified BODIPY-MXene nanoparticles,the antibacterial ability of the modified BODIPY-MXene nanoparticles has been improved to a certain extent.（2）The required Ti₃C₂T_xMXene was prepared using Ti₃AlC₂as a MAX precursor,and then blended with citric acid and glutathione precursors to load carbon quantum dots onto Ti3C2T_xnanosheets under high temperature and pressure to obtain CQD-MXene.The photothermal performance of the sample was tested using an MDL-Ⅲ(808 nm,1.5 W·cm^-2)laser light source.Through analysis and calculation of the data,the photothermal conversion rate was 59.8%.First,the photothermal sterilization was conducted through suspension co culture,and then the photothermal sterilization performance of CQD-MXene against Staphylococcus aureus and Escherichia coli was measured using a dilution plate.Without laser irradiation,it had little impact on the growth of bacteria,As it can be analyzed that its antibacterial ability in the province is weak,after adding 808 nm laser irradiation,when its concentration is 120μg·m L^-1the bactericidal efficiency of reaches or approaches100%.