Design, Synthesis And Biological Activity Study Of Novel Fungicidal Compounds Based On Photo-controlled Azobenzen

Controllable and on-demand delivery of supramolecular systems have received considerable attention in the field of modern agricultural management,especially with regard to the management of intractable plant diseases.Here,we report an intelligent photoresponsive pesticide delivery system based onβ-cyclodextrin（β-CD）and azobenzene,which overcome the resistance of phytopathogens caused by the irrational use of conventional pesticides.Antibacterial bioassays illustrated that designed azobenzene derivative A₁possessed the most efficient bioactive with EC₅₀ values of 0.52～25.31μg/m L towards three typical phytopathogens.Moreover,the assembly of the supramolecular binary complex A₁@β-CD was elucidated successfully and displayed exceptional inhibitory activity on biofilm formation.Interestingly,this supramolecular binary complex significantly improved water solubility,foliar surface wettability,and showed marked light-responsive properties.In vivo anti-Xoo assays revealed that A₁@β-CD had excellent control efficiency（protective activity:51.22%,curative activity:48.37%）against rice bacterial blight pathogens,and their control efficiency could be elevated to values of 55.84%（protective activity）and 52.05%（curative activity）by UV-vis exposure.This study therefore offers new insights on the potential of host-guest complexes as a feasible pesticide discovery strategy characterized by a safe,biocompatible,light-responsive release,and antibiofilm properties for overcoming intractable plant bacterial diseases.