Study On Topology Optimization Design And Drug Release Performance Of Drug Controlled Release System

Compared with traditional medical methods,precision medicine can provide accurate and personalized medical services for patients.As an important part of precision medicine,precision administration plays an important role in the realization of precision.However,traditional administration methods such as oral administration and injection not only cause fluctuation of blood concentration in vivo,but also have low curative effect and large side effects.Therefore,drug controlled release system with stable,sustained,efficient and low side effects has become the focus of research.In view of the problem that the conventional structural optimization method had limited regulation on the drug release law,this paper combined the topological optimization method with the structural design of drug controlled release system.The topology optimization design of drug controlled release system was carried out with the optimization goal of controllable concentration in the cavity,and the drug release performance was studied.The main research contents are as follows:Firstly,based on the physical model of drug carrier and Fick diffusion law,the drug release model of drug controlled release system was established-The topological optimization model of drug controlled release system was established based on the variable density method,and the design variables were post-processed through density filtering and projection.Secondly,the values of key parameters in the optimization model affected the average concentration in the design domain and the channel topology,and the concentration distribution was closely related to the flow topology.Based on the established topological optimization model,the range of target concentration in the design domain was determined,and the influence of key parameters such as mesh size,penalty coefficient,target concentration and volume constraint factor on the optimization results of drug controlled release system were studied and analyzed.The reasonable topological optimization model parameters were determined,and the relationship curve between the maximum adjustable target concentration and the volume constraint factor was established.Thirdly,the geometric reconstruction of the drug carrier topology was completed,and the transient simulation was carried out from the effects of different drug storage shapes,volume constraints and channel structures on the drug delivery capacity of the carrier.The introduction of the channel not only shortened the time for the carrier to reach a stable release state,but also improved the average concentration level in the design domain.Finally,the carrier without channel,topology optimization channel,triangular channel and rectangular channel were prepared by molding method,and the in vitro drug release experiment was carried out by using 37℃ phosphate buffer solution to simulate body fluid,which verified the rationality of theoretical research and the advantages of topology optimization in the structural design of drug controlled release system.This paper provides a new method for the structural parametric design of drug controlled release system and a new idea for the personalized customization of drug release rules in the process of precision medicine.