Study On The Preparation And Controlling Capability Of Chitosan-Based Transdermal Controlled-Release Membranes

The development of the preparation and controlling capability of chitosan-based transdermal controlled-release membranes are studied in this paper.Chitosan was chosen as the controlling materials for the transdermal drug delivery system, and the conditions of preparing chitosan membranes were researched. The results show that the optimized conditions for preparing chitosan membranes as follows: molecular weight of chitosan 40,000 dalton, concentrations of chitosan solution 2.0% (w/w), concentration of acetic acid 2.0% (w/w), concentration of sodium hydroxide solution 2.0% (w/w).In order to improve the plastic character, chemical and hole-size stability of the chitosan membranes, glutaraldehyde and glycerol were adopted when chitosan-based composite membrane was prepared. Two kinds of chitosan-based composite membranes (Type I and Type II) were prepared, and properties of these two types of chitosan-based composite membranes were evaluated by membrane intensity, swelling behavior, plastic character and permeability.The influence on permeability of Type II composite membrane effected by dosage of chitosan, glutaraldehyde and glycerol was studied by the Two Level Factorial Design software (Stat-Ease?). The relationship between the permeability coefficient of membrane (P) anddosage of chitosan (A) and glutaradehyde (B) can be described by the model: P=0.28-0.46* A-0.10xB+0.20*AxB. The validity of the model and parameter was also evaluated.The Type II composite membrane was chosen as the controlled-release membrane for preparing the hydrocortisone transdermal drug delivery system, release characteristics of this transdermal drug delivery system was evaluated in vitro. Results show that release characteristics of the transdermal drug delivery system observes Higuchi equation, for which the kinetic constant k was 21.18 ug ?cm"2?h"1/2. The results can be used to guide to the development of transdermal drug delivery system for drugs, such as estradiol, testosterone and Yun Nan Bai Yao, which have similar structure to hydrocortisone.