Synthesis Reaction Of Sulfur-promoted Arylonitrile And Benzo[1,4]Oxazin-2-one

Benzo[1,4]oxazin-2-one is a heterocyclic structure widely found in organic compounds,and its derivatives often possess good biological activities,such as antibacterial,accelerated coagulation and antiviral.Common methods for the synthesis of benzo[1,4]oxazin-2-ones often require transition metal catalysis or more demanding reaction conditions.Therefore,it is important to develop a new method for the simple and efficient synthesis of benzo[1,4]oxazin-2-one derivatives.Nitrile compounds are a class of commonly used intermediates in organic synthesis and an important component of many drug molecules,natural products and other biologically active molecules,which are widely used in pharmaceutical,organic synthesis and materials synthesis.Traditional methods for the synthesis of nitrile compounds include Sandmeyer reaction,dehydration of amides or oximes and Rosenmund-von Braun reaction,etc.However,these methods often have problems such as the use of toxic metal reagents,harsh reaction conditions and complicated operation.Therefore,the development of new low-cost and environmentally friendly methods for the synthesis of nitrile compounds is of great research importance.Based on the above research background,the main work of this thesis consists of the following two parts.(1)A new method for sulfur-promoted one-step synthesis of benzo[1,4]oxa zin-2-one derivatives was developed.The method is simple to operate without t he addition of oxidants and metal catalysts,and is easily scalable to the gram scale.The method provides a simple and economical new approach for the syn thesis of benzo[1,4]oxazine derivatives.(2)A new method was developed for the direct conversion of benzylamine promoted by sulfur powder to nitrile compounds in one pot without metal catalysts.The method is inexpensive in terms of raw materials,does not require metal catalysts and synthesizes the corresponding nitrile compounds in higher yields.The reaction is more tolerant of functional groups and is simple and easy to achieve gram-scale reactions in expanded amounts.This method provides a new method for the synthesis of nitrile compounds under mild conditions and simple operation,which has good application prospects.