A New Antibacterial Strategy Based On Active Natural Products And Nanozymes

Bacterial infection seriously threatens human life and health.The use of antibiotics is the most commonly used treatment antibacterial infection.However,due to the abuse of antibiotics,the problem of bacterial resistance is serious.Although new antibiotics are being developed,unfortunately,the current rate of development of new antibiotics is far slower than the emergence of bacterial resistance.Therefore,it is imperative to actively develop other antibacterial infection strategies that can replace the use of antibiotics.The numerous natural products with antibacterial properties in nature provide a rich source of medical development.In addition,as a new type of artificial nanozyme with enzyme-like activity,nanozyme has been widely used in the field of nanomedicine,and its antibacterial infection performance has been gradually discovered in recent years.In this paper,two different antibacterial strategies were developed by utilizing the antibacterial advantages of natural active products and nanozymes.The main research contents include:(1)The use of natural antibacterial products to build a new antibacterial strategy is considered an effective way to inhibit the rapid drug resistance.This paper used the natural active substance(allicin)and the fruit skin with rich porous structure as antibacterial agent and biological scaffold respectively.The natural antibacterial foam patch was obtained by simple stripping and extraction process.In the article,the antibacterial performance and mechanism of the natural antibacterial patch were discussed through a series of experiments such as agar diffusion method,plate counting method,fluorescence staining,and scanning electron microscope.The results showed that this natural antibacterial patch has high efficiency and broad spectrum antibacterial activity.In addition,the experiment of small animal skin wound infection model also proves that antibacterial patch has excellent antibacterial properties and the activity of inhibiting wound infection.The work provides new ideas for using natural substances to build antibacterial foam materials.(2)Antibacterial strategies based on natural active antibacterial components are often limited by their poor stability.Under the inspiration of previous work,we successfully loaded platinum nanoparticles on the surface of ZIF-8 coated with polydopamine by in-situ reduction method,and obtained a nanocomposite ZIF-8@PDA@Pt NPs with high peroxidase activity and excellent photothermal conversion performance.On this basis,we use the singlet oxygen and superoxide anion produced by catalytic hydrogen peroxide as well as its own photothermal effect to realize the chemical kinetics and photothermal synergistic antibacterial strategy.In addition,a series of vitro antibacterial experiments and mouse wound infection experiments have also confirmed that the nanocomposite not only has excellent antibacterial properties,but also shows good biocompatibility.The work also provides ideas for designing nanomaterials with efficient enzyme catalytic activity,but also provides effective guidance for the development of high efficiency synergistic antibacterial strategies.