Study On Slow-Release Performance Of Hypotensive And Hypolipidemic Drugs Over Carbonaceous Materials With Different Morphologies

Cardiovascular disease is a kind of disease that seriously endangers human health.Hypertension and hyperlipidemia are important risk factors for the occurrence of cardiovascular disease.Nifedipine and lovastatin are important drugs for lowering blood pressure and blood lipids.Organic carriers are generally used in the design of sustainedrelease drugs,but there are few studies on inorganic carriers.In this paper,three kinds of mesoporous carbon-based materials with different morphologies were prepared,and the loading and sustained-release properties of drugs for lowering blood pressure and blood lipids were studied in order to find a suitable carbon-based material as a drug carrier for the study of sustained-release properties.The main research contents are as follows:1)preparation of mesoporous carbon nanospheres and study on the sustained release properties of model drugs: mesoporous carbon nanospheres were synthesized by a simple and novel limited pyrolysis method of silica shell.The loading and release properties of nifedipine and lovastatin were studied by using the prepared mesoporous carbon nanospheres as carriers.The experimental results show that mesoporous carbon nanospheres have large specific surface area,and the maximum loading amounts of nifedipine and lovastatin are 96.9±0.51 μg/mg,99.4±0.42 μg/mg,respectively.The results of sustained release experiments showed that the release amount after 12 hours was 83.6±0.54% and 80.5±0.47%,respectively.2)preparation of wrinkled carbon nanospheres and study on the sustained release properties of model drugs: silica solid / resin composite spheres with different sunken degrees were prepared by changing the feed interval in the assembly process,using ethyl orthosilicate(TEOS)as silicon precursor and resorcinol formaldehyde(RF)resin as carbon precursor.The prepared fold hollow mesoporous can better encapsulate the drug in the cavity.As a high-quality carrier,the loading amount of nifedipine and lovastatin is 112.6±0.69 μg/mg,107.5±0.78 μg/mg,and the release amount after 12 hours is 90.1±0.18%,88.8±0.45%,respectively.3)preparation of nitrogen-doped mesoporous carbon spheres and study on the sustained release performance of model drugs: with dopamine carbon spheres as the core,dopamine and melamine could be used as carbon and nitrogen sources at the same time,and TEOS was added to adjust the surface morphology of nitrogen-doped mesoporous carbon spheres to obtain nitrogen-doped mesoporous carbon nanoparticles with rough surface.Nifedipine and lovastatin were used as model drugs to study the loading capacity and release performance of nitrogen-doped mesoporous carbon spheres as drug carriers.The results showed that the nitrogen content of mesoporous carbon spheres prepared by adding 0.3 m L TEOS was 4.87%,the loading amount of nifedipine and lovastatin was 126.8±0.58 μg/mg,121.9±0.63 μg/mg,and the release amount reached 96.4±0.42%,95.2±0.44% after 12 hours,showing a good sustained release effect.Based on the above experimental results,by comparing the loading of nifedipine and lovastatin,it is found that the loading of nifedipine is better than that of lovastatin.The performance of nitrogen-doped mesoporous carbon spheres is better.The introduction of nitrogen can improve the hydrophobicity of carbon materials,increase the hydrophilicity and wettability of carbon materials,thus increasing the drug loading.And its pore diameter and specific surface area are relatively large,which is more conducive to the release of drugs.