High Specific Surface Area Porous Carbon-based Materials For The Sustained Release Performance Of Ibuprofen

Ibuprofen has effects of anti-inflammatory,antipyretic,and analgesic,but it has the disadvantages of short half-life and large side effects.It is necessary to carry out sustained-release studies on it to reduce the physical and mental pressure of patients during use.Porous carbon-based materials with high specific surface area have good application prospects in the field of drug sustained release.In this paper,using the template method to prepare high specific surface area porous carbon materials with different morphologies,and conducts exploratory research on their loading and release behaviors.The main research contents of the paper are as follows:1)Mesoporous carbon spheres(MCs)was prepared using the confined pyrolysis method.MCs has high specific surface area and applied to the study of the sustained release performance of ibuprofen.This experiment,using resorcinol-formaldehyde(RF)resin as the carbon source,and silica as the hard template.Under the catalysis of ammonia and iron,it was compared with the carbon spheres obtained by unrestricted pyrolysis.Using MCs as a carrier to study the sustained-release performance of ibuprofen and loading isothermal and loading kinetics was used to analyze and study its loading behavior;Using the zero-order kinetic model,the first-order kinetic model,the Huguchi model and the Rigter-Peppas model to fit and analyze the in vitro release of ibuprofen-loaded MCs,studying their sustained release performance.2)Nitrogen-doped honeycomb three-dimensional ordered macroporous carbon(N-3DOMC)which has high specific surface area was synthesized by the colloidal crystal template strategy and applied to the study of the sustained release properties of ibuprofen.Both the nitrogen source and the carbon source are dopamine(DA),and polystyrene/polyacrylonitrile(PS/PAN or PSPAN)and ethyl orthosilicate(TEOS)are used as hard templates.TEOS is added at the same time as the carbon source to remove TEOS.After forming a hole between carbon and carbon,the overall shape of the product will not lose the shape of the PSPAN template,and the specific surface area can be adjusted by changing the amount of DA.Using N-3DOMC as a carrier to study the sustained-release performance of ibuprofen,loading isothermal and loading kinetics to analyze its loading behavior.The zero-order kinetic model,the first-order kinetic model,the Huguchi model and the Rigter-Peppas model were used to analyze the in vitro release of ibuprofen-loaded N-3DOMC to study its sustained release performance.3)Nitrogen-doped hollow carbon spheres(N-HCS)with high specific surface area were prepared by a simple one-pot method and applied to the study of the sustained release properties of ibuprofen.Among them,the carbon and nitrogen sources are both DA,and the PSPAN sphere is used as a template to form a hollow structure.The influence of F127 and mesitylene(TMB)on the morphology and specific surface area is explored.Using N-HCS as a carrier to study the sustained release performance of ibuprofen,and use loading isothermal loading kinetics to study its loading behavior.To explore its sustained-release performance,using the zero-order kinetic model,first-order kinetic model,Huguchi model and Rigter-Peppas model to analyze the in vitro release of ibuprofen-loaded N-HCS.