Construction Of Textile-based Transdermal Delivery System And Studies Of Transdermal Drug Delivery

Transdermal drug delivery system(TDS)is a non-invasive drug delivery system,which acts on the skin and can deliver drugs to the blood circulation through the skin surface to play a systemic role.This method of administration can avoid gastrointestinal "first-pass effect",and has the advantages of high patient compliance and low side effects.At present,the existing transdermal drug delivery system is not effective enough.This is due to the dense "brick-sand" structure composed of keratinocytes and intercellular substance,which usually requires the assistance of external equipment and instruments or special drug delivery carriers,and is not simple and flexible enough to use.In addition,the backing layer in the prepared system is mostly membrane structure,which is easy to fall off and weaken the transdermal effect due to insufficient fit in actual use,as well as poor comfort.In this paper,a textile based transdermal drug delivery system was designed and prepared.With adhesion and permeability as indicators,the preparation process parameters were optimized to prepare a multilayer structured patch.The thickness of drug carrier layer is 0.5mm,and the formula of PSA(g): MT(g)=47:1,PSA(g): ethyl acetate(ml)=10:1 is determined.According to the infrared spectrum and distribution coefficient determination,there is no adsorption and chemical combination between the PP material and the model drug.Finally,60g/m2 of PP non-woven fabric is selected as the backing material.The transdermal drug delivery system that can control the drug delivery effect is prepared by loading physical and chemical control methods on the infrastructure.The PSA component of the drug carrier layer was screened,and Duro Tak 387-2510 was selected as the polyacrylic acid pressure sensitive adhesive material.The changes of in vitro release and percutaneous diffusion were investigated under different control methods.The results showed that menthol mainly acts on the stratum corneum and active skin,azone more acts on the intercellular lipids in active skin,and oleic acid mainly acts on the lipid bilayer of stratum corneum.According to the experimental results,the optimal chemical regulation parameters are 5% menthol,5% azone,and 10% oleic acid.Both positive and negative electrets can promote the model drug,and the higher the electret strength is,the more obvious the promotion effect is,and the more obvious the promotion effect is.Under the same electret strength,the penetration promotion effect of negative electrets is higher than that of positive electrets.Therefore,the preferred physical regulation parameters are-500 V,-1000 V,and-1500 V electrets.Two factor and three level orthogonal test was designed for the optimization parameters.The results showed that oleic acid and electret had the best effect on the military lipid structure and disturbing the tight structure of lipids.Therefore,the final optimal synergistic formula was 10% oleic acid and-1500 V electret.Fitting the transdermal diffusion data of the optimal prescription parameters,the results showed that the Higuchi fitting had the highest correlation coefficient,0.99357.The Higuchi model was the relationship model between drug release amount and time in the homogeneous skeleton and heterogeneous porous skeleton solid preparations,indicating that the prepared transdermal drug delivery system MT was uniformly dispersed and dissolved in the PSA skeleton,and the drug was released through the pores in the skin.Finally,a rat transdermal drug delivery model was established.The content of MT in plasma was determined by HPLC,and the skin irritation of the transdermal drug delivery system was observed.The ratio of MT content through the skin barrier to the total MT content in the control group and the experimental group was 52.99% and 80.23%,respectively.The optimal synergistic transdermal drug delivery parameters can improve the permeability of MT to the skin barrier,with high bioavailability.The designed transdermal drug delivery system is applicable to organisms.According to the observation of rat skin expression before and after the experiment,the prepared transdermal drug delivery system has weak skin irritation and sensitization and high safety.