Studies On Tandem Reaction Of Synergistic Phosphonylation Of Ketones Catalyzed By Lewis Acid

Organic phosphine compounds are valuable multifunctional molecules,which are widely used in industry,agriculture,biomedicine and organic catalysis because of their unique chemical properties and biological activities.Therefore,it is particularly important to develop an efficient,economical and simple strategy to synthesize organic phosphine compounds.In this paper,a new strategy for the construction of organic phosphine compounds was developed after summarizing the relevant literature of predecessors.Organic phosphine compounds are constructed mainly by phosphine acylation of ketones.This kind of method has the characteristics of mild reaction,green reaction and economy,which provides a certain theory and reference value for the synthesis of organic phosphine compounds.This paper contains the following four parts:1.The strategies for α-substituted olefin synthesis by transition metal catalysis and coupling in recent years are classified.The functional groupation of carbon-carbon bonds,carbon-hydrogen bonds and carbon-heterobonds in transition metals is introduced in detail,and strategies for the construction of photoreactions and free radical reactions are also covered.2.This chapter mainly introduces the Lewis acid-catalyzed ketophosphonylation tandem reactions.We used ketones as raw materials and alkyl phosphites as phosphonylation reagents to synthesize a variety of α-alkenyl phosphonates.This strategy allows the efficient synthesis of a series of alkenyl phosphonate compounds with the only by-product being water,which has the advantage of being green and in line with the tenet of green chemistry.The proposed strategy provides a valuable reference for acid-catalyzed phosphonylation reactions.3.This chapter mainly introduces the research status of 9-substituted fluorene derivatives from six aspects.Through the different reaction process,the different synthesis strategies and their application status are briefly discussed.4.A two-component "one-pot" synthesis of 9-phosphonofluorene compounds were synthesized by a two-component "one-pot" method using aluminum trifluoromethanesulfonate as a cheap Lewis acid catalyst for the phosphonylation of ketones.The reaction of benzophenones with various phosphine sources was achieved in high yields by using benzophenones as substrates.The products were further converted to a series of organophosphine compounds by oxidation,substitution and other derivatization reactions,and the bisphosphine ligands containing fluorene skeletons were further obtained by simple reduction.The research in this paper is based on the experimental purpose of mild reaction,high atomic economy and green color,which provides innovative and applied research value for the synthesis strategy of phosphinylation of ketones,and provides new methods for the synthesis of phosphine-containing ligands,intermediates and other compounds,which is different from the traditional base-catalyzed synthesis of phosphine-containing compounds and provides new ideas for the acid-catalyzed synthesis strategy.