Preparation And Properties Of Antibacterial Coatings Of Copper-loaded Titanium Dioxide Nanorods On The Surface Of Medical Titanium

Titanium（Ti）and its alloys have been widely used in dentistry,orthopedic,and cardiovascular stents and other fields due to their good mechanical property,corrosion resistance and biocompatibility.However,titanium（Ti）and its alloys lack biological activity and antibacterial ability,which makes it difficult to fuse with forming bone,and cannot avoid problems such as inflammation and allergic reactions due to corrosion and microbial infection after implantation in living organisms.Therefore,in this paper,titanium dioxide（TiO₂）nanorods was first synthesized on the surface of titanium plate,and then nano-copper（Cu）was loaded by ion implantation and polymer-mediated self-assembly method to obtain the antibacterial coating of Cu-loaded TiO₂ nanorod on the surface of medical titanium.The composition,structure and antibacterial property of the antibacterial coating were studied.The main research works and results are as follows:（1）TiO₂ nanorods was synthesized on the surface of titanium plates by hydrothermal method,and the effect of preparation process conditions on the morphology of TiO₂ nanorods was investigated.The results showed that the addition amount of precursor had the greatest influence on the morphology;the TiO₂ nanorods prepared by adding 1.17μmol of precursor（denoted as TNR-2）presented a complete and separate rod-like structure with good corrosion resistance and hydrophilicity.（2）Copper ions were implanted into TNR-2 by ion implantation technology to obtain the antibacterial coating of Cu-loaded TiO₂ nanorod on the surface of medical titanium（denoted as Cu-TNR-2）,and its composition,morphology and antibacterial property were studied.The results show that:Cu-TNR-2 still exists in the nanorods structure,and copper exists on the surface in the form of atomic nanoparticles;the hydrophilicity and corrosion resistance of the titanium plate were improved after ion implantation;the antibacterial rates of Cu-TNR-2 against both Escherichia coli and Staphylococcus aureus exceeded 99%;Its hemolysis rate is less than 5%and MC3T3-E1 cells can grow well on its surface.（3）Copper was loaded on TiO₂ nanorods by polymer-mediated self-assembly method to obtain the antibacterial coating of Cu-loaded TiO₂ nanorod on the surface of medical titanium（denoted as TiO₂@Cu/Ti）,and its composition,structure and morphology were characterized.The results showed that:the core-shell structure of the nanorods TiO₂@Cu/Tiwas formed,and copper formed a continuous nano-shell on the surface of TiO₂ nanorods in atomic state;the antibacterial rates of TiO₂@Cu/Tiagainst Escherichia coli and Staphylococcus aureus exceeded 99%;TiO₂@Cu/Tihas good hydrophilicity and corrosion resistance;Its hemolysis rate is less than 5%and the relative survival rate of MC3T3-E1 cells on its surface is 98%,indicating its good biocompatibility.