Synthsis And Characterization Of Rare Earth/Mesoporous Silica/Sensitive Polymer Nano-hybrid Materials

Over the past decades,lots of efforts were made to synthesize stimuli-responsive nanospheres which were sensitive to various external stimuli.These composites can be applied in biochemistry and biomedical fields.DOX is an effective and commonly used anti-cancer drug for the treatment of human malignant tumor.However,due to the relatively short biological half-life and non-specific distribution,DOX’s toxicity limits its application in the field of drug release.As a single chemical compound,DOX has high toxicity,good solubility and high affinity,but it could not be used directly in the human body.Therefore,people have tried to design nanomaterials loading with DOX to enhance the distribution of drugs in the body,which could enhance the deposition of tumor sites and reduce cytotoxicity.Mesoporous silica shows large surface area,whose pore size,particle size and particle shape could be adjusted.Mesoporous silica shows mechanical stability and is an excellent carrier.However,mesoporous silica could not be used to accurately control drug release.Therefore,a polymer layer coated on silica was used to prepare the smart stimuli-responsive carrier which could stimulate the tumor’s micro environment in response to extra stimulate.In part 1,MCM-41 was prepared by hydrothermal synthesis as a carrier.A single temperature-responsive polymer PNIPAM was coated on the surface of MCM-41,while rare earth luminescent material was grafted on the surface.These fluorescence materials could be tracked in the human body.The material was characterized by SEM,TEM,DLS,TGA,IR,UV-vis,fluorescence,BET,drug loading and release and cell experiments.The drug release of DOX-loaded materials at different temperatures and the toxicity were investigated.The nanomaterial at high temperature shows the higher release rate.In part 2,a dual-stimulus-responsive polymer P(NIPAM-co-MAA)with temperature/pH sensitivity was prepared.Finally,MCM-41/P(NIPAM-co-MAA)/EUW10 was synthesized.The material was characterized by SEM,TEM,DLS,TGA,IR,UV-vis,fluorescence,BET,drug loading/release and cell experiments.The nanomaterial at low pH and high temperature shows higher release rate.In part 3,a dual-stimulus-responsive polymer PNIPAM-g-CS with temperature/pH sensitivity was prepared.Finally,MCM-41/PNIPAM-g-CS/EuW10 composite material was synthesized and it was characterized by SEM,TEM,DLS,TGA,IR,UV-vis,fluorescence,BET,drug loading/release and cell experiments.The nanomaterial at low pH and high temperature shows higher release rate.