Study On The Emotional Circuit Based On Intracranial Electrical Stimulation In The Orbitofrontal Cortex

Emotion is an important psychological activity of human beings and plays an important role in people’s daily life.However,there are many diseases in the world that can lead to excessive emotional reactions,such as depression,anxiety,and mood disorders.Depression is the third most common disease in the world.According to the World Mental Health Survey,in high-income and low-income countries,the percentage of patients with depression in the total population is 14.6% and 11.1%,respectively.Many existing studies have begun to use neuroregulatory techniques to intervene in specific brain regions to improve the emotional state of patients with mood disorders.Intracranial electrical stimulation(i ES)is an excellent method for treating refractory mood disorders.However,some existing studies on intracranial electrical stimulation lack effectiveness,and there are problems in finding suitable stimulation locations,confirming stimulation timing,and analyzing the impact of i ES on the activity of emotional network brain regions.In response to the existing problems of intracranial electrical stimulation,thesis analyzed public data using the following three studies: 1)Based on the relationship between mood and brain power in patients with baseline state,thesis searched for biomarkers of mood state changes,and then compared and analyzed the effects of stimulating the orbitofrontal cortex(OFC)brain region and other brain regions in the treatment of mood disorders to determine suitable regulatory targets;2)Training machine learning models to predict emotions to distinguish the state of the patient’s brain,and then comparing and analyzing the effects of different state regulation to find the appropriate time for regulation;3)Analyze the power patterns,undirected connections,and directed connections of the brain network,and study the impact of i ES on the activity of brain regions within the emotional network.Based on the above analysis,thesis finds that: 1)Only stimulating the OFC,but not other regions can improved emotional state,and significantly reduced the delta-theta frequency band power;2)According to the results of the machine learning model,brain activity before stimulation can be divided into high and low states.Only in low states,the power in the delta theta frequency band significantly decreases after regulation,improving emotions,while in high states,the low frequency power does not decrease significantly;3)Stimulating OFC reduced delta-theta power,increased gamma power,and also increased directed and undirected connections within the brain network.In summary,thesis found that OFC is a potential intracranial electrical stimulation target.In addition,it was found that the effect of intracranial electrical stimulation is state dependent,and the lower the brain activity state,the better the regulatory effect.It also revealed the changes in brain activity and connectivity of emotional networks caused by intracranial electrical stimulation.The findings of thesis provide important guidance for precise intervention and treatment of emotional disorders and mental disorders in the future.