The Effectors Of The Method Of Promoting Blood Circulation To Remove Blood Stasis On Hemorheology Indices In Liver Cancer Patients With Blood-stasis Syndrome

Objective:By observating the change of hemorheology indexes and therapeutic effect of blood-stasis syndrome of liver cancer patients after applying Xuebijing injection to investigate therapeutic effects and clinical significance to the liver cancer patients with blood-stasis syndrome by using the method of promoting blood circulation to remove blood stasis.Methods:60 patients with primary liver cancer and blood-stasis syndrome selected were randomly divided into treatment group and control group (treatment group 30 cases and control group 30 cases). The treatment group add in the Xuebijing injection for 14 days continuously on the basis of symptomatic treatment, while applying the symptomatic treatment only in the control group. Observe the change of hemorheology indexes, therapeutic effect of TCM, blood analysis and liver and kidney functions to further discuss the therapeutic effects and clinical significance of promoting blood circulation to remove blood stasis to the patients with blood-stasis syndrome.Results:Using the method of promoting blood circulation to remove blood stasis can obviously reduce the patients’blood-stasis syndrome score and the total effective rate of treatment group were 93.33%. the treatment group was significantly superior to the control group in improving the blood-stasis symptoms such as pain, blood stasis in collaterals, mass in the abdomen accumulation, dysmenorrhea, amenorrhea, dark purple color tongue and petechial or bruise on the tongue, uneven pulse and numbness.The hemorheology indexes as the whole blood high viscosity, the whole blood middle viscosity, the whole blood low viscosity, hematocrit, erythro-agglutation index and stiffness index were obviously decreased in the treatment group after the therapy, and the difference was statistically significant (P< 0.05) between treatment group with control group.As for security, the result of blood analysis suggests that the level of leucocyte count, neutrophil count, neutrophil percentage, plaque count was reduced in the treatment group after the therapy and had remarkable difference (P< 0.05)by comparing with the control group, while the level of erythrocyte counts and hemoglobin content were similar in the treatment group before and after the therapy and there was no significant difference (P>0.05) between the treatment group and the control group after therapy. It indicates that the treatment has no harm to the patients’ blood system. The reduction of the level of leucocyte count, neutrophil count, neutrophil percentage, plaque count might be due to anti-inflammatory effect of Xuebijing injection. And the antiplatelet effect of herbs promoting blood circulation to remove blood stasis lead to reduction of the level of plaque count. About hepatonephric function, both group has no significant difference after the treatment (P> 0.05). It suggests that the treatment have no damage to the patients’ hepatonephric function.Conclusion:Applying Xuebijing injection to the liver cancer patients with blood-stasis syndrome in principle of the method of promoting blood circulation to remove blood stasis can significantly improve the patients’ symptoms of blood-stasis syndrome and reduce the level of the hemorheology indexes including the whole blood high viscosity, the whole blood middle viscosity, the whole blood low viscosity, hematocrit, erythro-agglutation index and stiffness index effectively, to improve the high condensation state of blood. It provides clinical basis for the treatment of liver cancer patients with blood-stasis syndrome.