The Distribution Of TCM Syndrome Elements In Non-valvular Atrial Fibrillation And Their Correlation With Coagulation Function

ObjectiveThrough retrospective study of cases,to explore the distribution of TCM syndromes of non-valvular atrial fibrillation,and analyze the correlation between TCM syndromes and coagulation function,so as to provide a reference for the study of TCM syndromes and treatment of non-valvular atrial fibrillation and the prevention of thrombus.MethodsAccording to the common symptoms of atrial fibrillation in the "ESC/EACTS Guidelines for the Diagnosis and Management of Atrial Fibrillation" and the symptom and syndrome element to design information scale by Syndrome Differentiation,the four diagnosis information in the admission record and the coagulation indicators of the test results were sorted out,and the database were established using Excel tables.The syndrome element is determined by the syndrome element score more than 20 points,and the disease location syndrome element and disease nature syndrome element are analyzed and extracted.SPSS25.0 software was used to analyze the correlation between TCM syndrome element integrals and coagulation function.Results1.A total of 140 patients with the first diagnosis of non-valvular atrial fibrillation were enrolled.The distribution of syndrome factors is as follows:(1)There are 7 syndrome elements involved in the disease location.The frequency and composition ratio from high to low are heart(77,55.0%),lung(53,37.9%),spleen(33,23.6%),kidney(24,17.1%),liver(9,6.4%),stomach(2,1.4%),meridian(2,1.4%).The main diseases are the heart and lungs.(2)There are 13 pathogenic elements involved in the disease.The frequency and composition ratio from high to low are qi deficiency(96,68.6%),phlegm(66,47.1%),yang deficiency(63,45.0%),yin deficiency(60,42.9%),blood deficiency(58,41.4%),dampness(31,22.1%),water stop(25,17.9%),blood stasis(18,12.9%),drinking(15,10.7%),qi Stagnation(9,6.4%),heat(5,3.6%),yang hyperactivity(4,2.9%),and cold(1,0.7%).Among them,deficiency syndromes are mainly qi deficiency,yang deficiency,yin deficiency,and blood deficiency.The substantial syndromes are mainly phlegm,dampness,water stagnation,blood stasis,drinking,and qi stagnation.(3)Combine the patient’s pathogenic elements,a total of 8 combinations are involved.The frequency and composition ratio from high to low are single syndrome element(30,21.4%),three syndrome elements combination(30,21.4%),and two syndrome elements combination(24,17.1%),four syndrome elements combination(16,18,6%),five syndrome elements combination(14,10.0%),six syndrome elements combination(6,4.2%),seven syndrome elements combination(5,3.6%),eight syndrome elements combination(5,3.6%).It mainly consists of single syndrome element and three syndrome elements combination.(4)Combine the syndromes of the patients with deficiency and disease,a total of 3 combinations are involved.The frequency and composition ratio from high to low are deficiency and substantial syndromes combination(81,57.9%),deficiency syndromes combination(43,30.7%),and substantial syndromes combination(16,11.4%).It mainly consists of deficiency and substantial syndromes combination.2.Select the pathogenic elements with frequency more than 10%,mainly including qi deficiency,yang deficiency,blood deficiency,phlegm,yin deficiency,blood stasis,dampness,and water stop,and count the points.Correlation analysis between disease syndrome element scores and coagulation indexes.(1)The scores of yang deficiency and dampness are positively correlated with the coagulation index PT(p<0.05),and there is a significant correlation between dampness and APTT(p<0.01).(2)The syndrome element scores of yang deficiency and yin deficiency are positively correlated with the coagulation index APTT(p<0.05).(3)The syndrome element scores of blood deficiency are positively correlated with coagulation indexes FIB,D-D,FDP(p<0.05),and there is a significant correlation between blood deficiency and FIB(p<0.01).Conclusions1.The disease location of patients with non-valvular atrial fibrillation is mainly in the heart,and there are also varying degrees of pathological damage to the lung,spleen,kidney,and liver.Deficiency disease location syndrome factors mainly include qi deficiency,yang deficiency,yin deficiency,and blood deficiency.The solid syndromes mainly include phlegm,dampness,water stagnation,blood stasis,drinking,and qi stagnation.2.Patients with non-valvular atrial fibrillation are mixed with deficiency and substantial syndromes,and most of them are single syndrome elements and a combination of three syndrome elements.Among them,deficiency of qi,blood,yin and yang are the main factors,and phlegm,water dampness,and blood stasis are the criteria.3.Non-valvular atrial fibrillation is related to the coagulation function.And APTT,PT,FIB,D-D,FDP levels are positively correlated with the scores of some syndrome elements.The level of coagulation index may indicate the severity of pathological factors.