Observation And Analysis Of Refraction Difference Value Of Peripheral Retina By Multispectral Refraction Topography

Objective: Multispectral refraction topography（MRT）was used to Observe and analyze of refraction difference value of peripheral retina,to explore the changing rule and its relationship with myopia,and discuss the possible mechanisms of myopia development.Methods: A cross-sectional study was used in this study.From January 2021 to December 2021,a total of 500 cases（500 eyes）aged 3～18 years old who visited the first Affiliated Hospital of Dali University and Dali Ophthalmology Hospital were collected as the research subjects.The ciliary muscle was complete paralyzed with dilation drugs.The spherical equivalent（SE）was measured by Computer optometry.Axial length（AL）and mean keratometer data（Km）were measured by optical biometrics.Intraocular pressure（IOP）was measured by non-contact tonometer.Multispectral refraction topography（MRT）was used to measure the refraction difference value in different field of vision（total refraction difference value TRDV,refraction difference value of the 15°retina RDV-15°,refraction difference value of the30° retina RDV-30°,refraction difference value of the 45° retina RDV-45°,refraction difference value of peripheral retina RDV-（53°-15°）,refraction difference value of the superior retina RDV-S,refraction difference value of the inferior retina RDV-I,refraction difference value of the nasal side retina RDV-N,refraction difference value of the temporal side retina RDV-T）.Part I: Clinical observation of the distribution characteristics of refraction difference value of peripheral retinal by multispectral refractive topography（MRT）in 3～18 year olds.Part II: The differences of refraction difference value of peripheral retinal among different populations were compared,and the correlation factors of refraction difference value of peripheral retinal were analyzed.Results: Part I: 1.500 cases of refraction difference value of peripheral retinal based on multispectral refractive topography（MRT）were classified into four types:volcanic mouth type（N=112）,hemiolateral upturned type（N=153）,saddle type（N=107）and relatively flat type（N=128）.The myopia rate of volcanic mouth type was 82.14%,hemiolateral upturned type was 69.28%,saddle type was 60.75% and relatively flat type was 3.90%.2.The myopia rate for hyperopia refraction difference value of peripheral retinal was 82.72%,and for myopia refraction difference value of peripheral retinal was12.72%.3.In the ring partition,RDV-45°> RDV-30°> RDV-15°,the hyperopia refraction difference value is most obvious when it reaches 45°,which can reach（0.20±0.37）D.4.In the quadrant partition,RDV-T > RDV-I> RDV-N > RDV-S,There was asymmetry between the superior retinal and the inferior retinal,nasal side and temporal sides.The hyperopia refraction difference value was the most obvious in the temporal side,which reached（0.58±0.69）D,and the myopia refraction difference value was the most obvious in the superior retinal,which reached（-0.26±0.67）D.Part II:1.The TRDV and RDV-（53°-15°）showed statistically significant differences among the three groups of different ages（P < 0.05）.Further pairwise comparison showed that:（1）The TRDV and RDV-（53°-15°）showed statistically significant differences between 3-8 years old group and 8-13 years old group（P < 0.05）.（2）The TRDV and RDV-（53°-15°）showed statistically significant differences between 3-8 years old group and13-18 years old group（P < 0.05）.（3）The TRDV and RDV-（53°-15°）showed statistically significant differences between 8-13 years old group and 13-18 years old group（P < 0.05）.2.The TRDV and RDV-（53°-15°）showed statistically significant differences among the three groups of different spherical equivalent（P < 0.05）.Further pairwise comparison showed that:（1）The TRDV and RDV-（53°-15°）showed statistically significant differences between hyperopia group and emmetropia group（P <0.05）.（2）The TRDV and RDV-（53°-15°）showed statistically significant differences between hyperopia group and myopia group（P < 0.05）.（3）The TRDV and RDV-（53°-15°）showed statistically significant differences between the emmetropia group and the myopic group（P < 0.05）.3.In myopic population,there were no statistically significant differences in gender,age,intraocular pressure and mean keratometer data between low myopia group and middle or high myopia group（P > 0.05）.There were statistically significant differences in axial length,TRDV,RDV-（53°-15°）,RDV-30°,RDV-45°,RDV-S,RDV-I,RDV-T between low myopia group and middle or high myopia group.（P < 0.05）.RDV-15 ° showed no significant difference（P > 0.05）.RDVN showed no significant difference（P > 0.05）.4.Pearson correlation analysis showed that refraction difference value of peripheral retina were positively correlated with age and axial length（P < 0.05）,negatively correlated with the spherical equivalent（P <0.05）,and had no correlation with gender,intraocular pressure and mean keratometer data（P > 0.05）.Conclusions: 1.In the ring partition,the larger the distance from macula and the increase of field angle.is,the larger the refraction difference value of peripheral retina is.In the quadrant partition,the refraction difference value of peripheral retinal was asymmetrically between the superior retinal and the inferior retinal,nasal side and temporal sides.The hyperopia refraction difference value was the most obvious in the temporal side,and the myopia refraction difference value was the most obvious in the superior retinal.2.The refraction difference value of peripheral retina was not consistent in different ages and spherical equivalent.The hyperopia refraction difference value increase with the increase of age,the decrease of spherical equivalent.The hyperopia refraction difference value may promote occurrence and development of myopia to a certain extent.3.According to the classification characteristics of refraction difference value of peripheral retina by multispectral refraction topography（MRT）,the refractive state and refractive development can be predicted quickly.This provides a convenient and reliable method for clinical.Multispectral refraction topography（MRT）,a new indicator,has a reliable and accurate guiding role in the myopia prevention and control,and is worth promoting in clinical.