A Preliminary Study On The EEG Characteristics Of Subjective Cognitive Decline People Carrying Apolipoprotein ε4/ε3 Genotype

Research Purpose:By observing the neuropsychological and EEG spectrum changes in subjects with subjective cognitive decline(SCD)patients and healthy subjects,to investigate the EEG characteristics of patients with SCD.Research Objects and Methods:Bring into 12 case of subjects each in accordance with the Frank Jessen SCD diagnostic framework in 2014(SCD group)and matched healthy elderly subjects(NC group).All subjects have completed the apolipoprotein E genotyping test,of which SCD group is Apoε4/ε3,and the NC group is Apoε3/ε3.All subjects first used the Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)to assess and exclude anxiety and depression,and the Hachinski Inchemic Score(HIS)to exclude vascular cognitive impairment(VCI),simple Mental State Examination Scale(MMSE)and Montreal Cognitive Assessment Scale(MOCA)assess cognitive function.All subjects have completed the apolipoprotein E(ApoE)genotyping test and collected 64-lead resting state EEG(rEEG),perform power spectrum analysis on rEEG data according to different genotypes,and statistically compare the differences in MMSE,MOCA scales and rEEG data between the two groups of subjects.Research Results:MOCA score was not statistically significant(t=1.254,P=0.233),MMSE score(t=6.055,P=0.371)was not statistically significant(>0.05);EEG spectrum analysis of each brain area in SCD group and NC group,The main effect of δ band in each brain area is not significant,F(3,66)=11.77,P>0.05,the main effect of factors between the two groups is not significant,F(1,22)=2.07,P=0.164;each brain area θ The main effect of frequency band is not significant,F(3,66)=14.87,P>0.05,the main effect of factors between the two groups is not significant,F(1,22)=0.67,P=0.421;the main effect of a frequency band in each brain area is not significant,F(3,66)=10.59,P>0.05,the main effect of the factors between the two groups is not significant,F(1,22)=1.25,P=0.276;the main effect of the β band in each brain area is not significant,F(3,66)=20.88,P>0.05;the main effect of factors between the two groups is not significant,F(1,22)=1.24,P=0.278;each brain area of the SCD group and NC group(δ+θ)/(α+β)Value comparison(x±s).The frontal area difference was statistically significant(P<0.05).Conclusions:1.The preliminary results showed that the score of the MOCA scale(27.000±0.953)and the MMSE scale(27.250±1.055)had no significant predictive effect on SCD.However,the sample size of this study is small,and the sample size needs to be expanded for in-depth research.2.There was no difference in the absolute power of EEG in each brain area between the SCD group and the NC group(P>0.05),but the ratio of the slow wave(δ+θ)frequency band to the fast wave(α+β)frequency band in the frontal area of the SCD group increased(P<0.05),which may provide an electrophysiological reference basis for early identification of SCD.