| Background: Cerebral infarction（CI）is one of the common diseases in neurology.It has five characteristics: high incidence rate,high disability rate,high mortality,high recurrence rate and high economic burden.Atherosclerosis is an important cause of its pathogenesis,Relevant studies have shown that intracranial atherosclerotic stenosis（ICAS）plays a major role.Early identification of ICAS lesions and analysis of ICAS related risk factors are very important for the prevention,treatment and prognosis of CI.At present,the clinical diagnosis of ICAS is mainly through imaging examination technology.Due to the relatively high cost,it is easy to be affected by the technology of operators,resulting in false positive or false negative;And limited by the severity of the patient’s condition and relevant contraindications;Therefore,it is very necessary for the treatment of cerebral infarction to collect relatively easy clinical indicators and early detect and identify ICAS in patients with cerebral infarction.Therefore,this study selects two common serological indexes-serum SAA and hs CRP,in order to explore their correlation with ICAS in patients with cerebral infarction,in order to provide a new therapeutic perspective for the treatment of ICAS in patients with atherosclerosis and cerebral infarction.Objective: To investigate the correlation between the level of serum amyloid A（SAA）,hypersensitive C-reactive protein（hs-CRP）and intracranial atherosclerosis（ICAS）stenosis in patients with cerebral infarction.And risk factors for ICAS in patients with cerebral infarction.Methods: From November 2020 to July 2021,137 patients with cerebral infarction admitted to The Department of Neurology,Chao hu Hospital Affiliated to Anhui Medical University were selected.including 107 patients with ICAS as the experimental group.Selected53 cases of dizziness complicated with ICAS in our hospital during the same period as control group.Baseline data of age,sex,blood uric acid,triglyceride,total cholesterol,high density lipoprotein,low density lipoprotein,hypertension,diabetes history,smoking history,drinking history and so on were collected for all subjects.And improve head MRI and head and neck CT angiography（CTA）to evaluate the degree of intracranial artery stenosis in patients with cerebral infarction.According to Samuels criteria,they were divided into non-ICAS group,mild ICAS group,moderate ICAS group and severe ICAS group.The levels of SAA and HS-CRP were detected by immunoturbidimetry.Serum SAA and Hs-CRP levels of experimental group and control group were compared and analyzed.To analyze the correlation between different degree of ICAS stenosis and serum SAA and Hs-CRP levels in patients with cerebral infarction.The risk factors of ICAS in patients with cerebral infarction were analyzed by ordered logistic regression.Results: Serum SAA and HS-CRP levels in experimental groups were significanty higher than those in control group,with statistical significance（P < 0.05）.The degree of intracranial artery stenosis in patients with cerebral infarction increased successively with the level of serum SAA and hs-CRP,and there was statistical significance in pairwise comparison（P < 0.05）.Ordered logistic regression analysis showed that serum SAA,Hs-CRP,UA and hypertension were risk factors for ICAS in patients with cerebral infarction（P<0.05）.The cut-off points of SAA and Hs-CRP for predicting ICAS were 2.25（m L /L）and 1.205（mg/L）,respectively,with AUC > 0.7,（P<0.01）.Conclusion: The increase of Serum SAA,Hs-CRP levels is significantly correlated with the occurrence and stenosis of ICAS in patients with cerebral infarction.In patients with cerebral infarction,high levels of serum SAA and Hs-CRP have certain predictive effects on the risk of ICAS.Serum uric acid and hypertension were the risk factors for the occurrence of ICAS in patients with cerebral infarction.Serum SAA and Hs-CRP were significantly correlated with cerebral infarction. |
