Study Of The Level Of Hypersensitive C-Reactive Protein And Non-Infectious Factors In Pregnant Women

Background Pregnancy is a special period experienced by women,and the relationship between inflammation and pregnancy has attracted much attention.More attention has been paid to the impact of severe inflammatory reactions caused by obvious symptoms of pregnancy infection on adverse pregnancy outcomes so far,however,subclinical inflammation during pregnancy cannot be ignored.Current studies suggest that the subclinical inflammatory state during pregnancy may have potential adverse effects on pregnancy outcomes and intrauterine development of the fetus.High-sensitivity Creactive protein（hs-CRP）is a highly sensitive inflammatory marker reflecting the inflammatory state of the body.Studies have shown that hs-CRP is one of the risk factors for adverse pregnancy outcomes such as gestational diabetes mellitus,gestational hypertension,and preterm birth.However,the level of hs-CRP in pregnant women without obvious infection symptoms and the non-infectious factors need to be explored.Objective To understand the serum hs-CRP level of pregnant women without obvious infection symptoms during pregnancy,and to explore the non-infectious factors affecting the hs-CRP level.Methods Pregnant women without obvious symptoms of infection who underwent obstetric examination at an obstetric outpatient department of a tertiary hospital in Anhui Province from December 2020 to December 2021 were selected.The sociodemographic data,pregnancy-related data,and life behavior data（pregnancy stress,passive smoking,alcohol consumption,physical activity level,etc.）of pregnant women were collected using a general data questionnaire,the dietary intake of pregnant women was collected using a food frequency questionnaire and the daily intake of nutrients was analyzed.The fasting serum of pregnant women was collected,and the serum hs-CRP level was detected by enzyme-linked immunosorbent assay.Univariate analysis and multivariate Logistic regression analysis were used to analyze the non-infectious influencing factors of hs-CRP levels in pregnant women.Results（1）A total of 664 pregnant women without obvious infection symptoms were included in this study,including 154（23.2%）pregnant women in the first trimester,320（48.2%）pregnant women in the second trimester and 190（28.6%）pregnant women in the third trimester.The level of serum hs-CRP in pregnant women was 1.9053（0.896 3.620）mg/L,of which 225 cases（33.89%）had serum hs-CRP levels beyond the normal range（≥3 mg/L）.（2）The results of univariate analysis showed that: among the sociodemographic and pregnancy-related indicators,there were statistically significant differences in educational level,per capita monthly household income,pregnancy period,pre-pregnancy BMI,primipara,and planned pregnancy between the normal serum hsCRP group and the high group（P<0.05）,there was no significant difference in age,place of residence and occupation between the groups（P>0.05）.The comparison results of life behavior indicators between the two groups showed that there were no significant differences in stress during pregnancy,physical activity,passive smoking,drinking,and whether taking folic acid supplements（P>0.05）.The comparison of dietary nutrient intake indicators between the two groups showed that the daily dietary fat and vitamin C intake during pregnancy were significantly different between the two groups（P<0.05）,the daily dietary energy intake,protein,carbohydrate,cholesterol,thiamine,vitamin E,dietary fiber,retinol,riboflavin,folic acid intake between groups had no significant difference（P>0.05）.（3）Multivariate Logistic regression analysis showed that primipara（OR =0.556,95%CI: 0.387~0.799）,planned pregnancy（OR =0.493,95%CI: 0.349~0.696）,bachelor’s degree or above（OR =0.384,95%CI: 0.200~0.738）,higher per capita monthly household income（>4000 yuan）（OR =0.154,95%CI: 0.053~0.450）and higher dietary vitamin C intake（OR = 0.997,95%CI: 0.995~0.999）were protective factor for high serum hs-CRP level during pregnancy.The course of pregnancy（OR=9.973,95%CI: 6.074~16.374）and pre-pregnancy BMI were higher（OR =1.234,95%CI: 1.160~1.313）and higher dietary fat intake（OR =1.009,95%CI: 1.003~1.014）were risk factors for elevated serum hs-CRP levels during pregnancy.Conclusion This study draws the following conclusions:（1）Some pregnant women without obvious infection symptoms have high serum hs-CRP,which should be paid attention to during pregnancy.（2）Primipara,planned pregnancy,bachelor’s degree or above,higher per capita monthly household income（>4000 yuan）,and higher dietary vitamin C intake are the protective factors for high serum hs-CRP levels during pregnancy The course of pregnancy,higher pre-pregnancy BMI and higher dietary fat intake are the risk factors for higher serum hs-CRP levels during pregnancy.