Study On The Relationship Between High-sensitivity C-reactive Protein And Intracerebral Hemorrhage

Objective: To investigate the dynamic changes of serum Hs-CRP (High Sensitivity C-reactive Protein) levels in patients with acute ICH (Intracerebral Hemorrhage), and the association between the dynamic levels and intracerebral hemorrhage; to ivestigate the relationship between the content of serum total cholesterol (Total Cholesterol, TC) and pathogenesis of cerebral hemorrhage.Methods: Detected the levels of serum Hs-CRP in different periods and serum TC in 60 patients with intracerebral hemorrhage and in 30 healthy cases, separately compared and analyzed. All patients with cerebral hemorrhage underwent cranial CT, counted intracerebral hemorrhagic volume in accordance with DuoTian calculation, and are divided into large, medium and small blood loss group in accordance with the standards. Compared the Hs-CRP levels with bleeding amount in patients with different periods of cerebral hemorrhage, and their correlations were analyzed. A correlation analysis also is made between the serum TC level and the onset risk of patients with cerebral hemorrhage.Results: The serum Hs-CRP levels in patients group with different periods of intracerebral hemorrhage were higher than the control group, and the differences had statistical significance (P≤0.05); the dynamic observation of serum Hs-CRP in patients with cerebral hemorrhage displayed that the serum Hs-CRP levels began to rise in 24h, increased significantly in 3d, and had a downward trend in the first 10 days; and that the serum Hs-CRP levels in 3d were higher than in 24h and 10d, and the differences had statistical significance (P≤0.05), serum Hs-CRP concentrations within the 10d and 24h had no significant difference ( P>0.05). Different bleeding amount group and normal control group were statistically significant (P≤0.05), the greater the amount of bleeding, serum Hs-CRP level is higher, but the large, medium and small group had no significant difference with each other (P>0.05); TC expressed in patients with cerebral hemorrhage was significantly higher than the normal control group, and compared with the control group the differences had statistical significance (P≤0.01).Conclusion: Hs-CRP have a certain correlation with the progression of cerebral hemorrhage; the dynamic changes of serum Hs-CRP level reflects the condition of inflammatory response and brain edema in cerebral hemorrhage, that may serve as an observed indicator to estimate the severity and prognosis of patients; there was no significant correlation between Hs-CRP levels and the size of cerebral hemorrhage volume.