| Research Purpose:In this study,by comparing the improvement effect of oral spray of normal temperature water and lemon water on the thirst feeling of patients with end-stage heart failure,we found out the intervention method that can effectively alleviate the thirst of patients with heart failure and is suitable for clinical use and promotion.Research Methods:The subjects of this study were selected from patients with end-stage heart failure in a grade III class A hospital in Huzhou city,Zhejiang Province from January 2021 to December 2021.70 patients were included in this study and randomly divided into control group and experimental group.During the intervention,there were 2 cases of shedding in control group and 3 cases of shedding in experimental group.In fact,there were 65 cases in total,including 32 cases in control group and 33 cases in experimental group.The visual analog scale（VAS）of thirst and the degree of lip,tongue and oral mucosa moisture were collected before intervention,on the first,third and seventh day of intervention.Saliva flow rate and thirst distress score（TDS-HF）for heart failure patients were collected before and after intervention.Statistical software was used to analyze the data.Two-sample independent T Test was used to conduct comparative analysis on the measurement data subject to normal distribution,and mann-Whitney Test was used to conduct comparative analysis on the measurement data and grade data of non-normal distribution.P<0.05 indicated statistically significant differences.In order to eliminate the effect of confounding factors and time,multiple repeated measure anova was used to judge the effect of intervention.Research Results:（1）Comparison of baseline data between the two groups: there were no differences in demographic data,clinical data and baseline drug use between the two groups（P>0.05）,indicating comparability.VAS value,lip,tongue and oral mucosa moisture level,saliva flow rate and TDS-HF score before intervention were compared between 2 groups,showing no difference（P>0.05）,which was also comparable.（2）Comparison of VAS value between the two groups: The VAS value of the experimental group on the first day of intervention was（3.42±0.82）lower than that of the control group（3.84±0.85）,but there was no difference（P>0.05）;On the third day of intervention,the VAS value of the experimental group（2.48±0.80）was significantly lower than that of the control group（3.47±1.05）（P<0.05）.The VAS value of the experimental group（1.52±0.62）was significantly lower than that of the control group（3.00±0.92）on the seventh day of intervention（P<0.05）.The results of repeated measure ANOVA showed that the VAS values of the control group and the experimental group were significantly different without considering the time factor（F=127.176,P< 0.05）.Regardless of grouping factors,VAS values at different time points were significantly different（F=14.308,P < 0.05）.There was an interaction between group effect and time effect（F=19.265,P < 0.05）.（3）Comparison of lip,tongue and oral mucosa moisture grade between the two groups: The Z value of lip,tongue and oral mucosa moisture grade distribution between the two groups on the first day of intervention was-1.002,with no difference（P>0.05）;On the third day of intervention,the Z value of lip,tongue and oral mucosa moisture grade distribution between the two groups was-3.703,with significant difference（P<0.05）.On the seventh day of intervention,the Z value of lip,tongue and oral mucosa moisture grade distribution between the two groups was-3.759,indicating a significant difference（P<0.05）.（4）Comparison of saliva flow rate between the two groups: after 7 days of intervention,the saliva flow rate of the experimental group（0.41±0.04）ml/min was higher than that of the control group（0.33±0.03）ml/min,there was a significant difference（P<0.05）;Comparison between the control group showed no difference in saliva flow rate between 7 days after intervention and before intervention（baseline）（P>0.05）,while there was a significant difference between the experimental group and before intervention（baseline）（P<0.05）.（5）Comparison of TDS-HF score between the two groups: TDS-HF score of the experimental group was（14.09±2.85）seven days after intervention The TDS-HF score was significantly lower than that of the control group（20.28±3.11）（P<0.05）.Meanwhile,intra-group comparison showed that t DS-HF score after 7 days of intervention in the control group was significantly lower than that before intervention（baseline）（P<0.05）,while intra-group comparison showed that TDS-HF score after 7 days of intervention in the experimental group was significantly lower than that before intervention（baseline）（P<0.05）.Conclusions:（1）This research adopts the lemonade and normal temperature water through the mouth spray intervention in patients with end-stage heart failure thirsty,results show that the lemonade than normal temperature water through the mouth spray can more effectively improve the patients’ saliva flow rate and patients’ oral oral mucosa moist degree,reduce the patients with thirst degree,significantly alleviate the degree of patients feeling thirsty,to improve the comfort and quality of life of patients.（2）The intervention method of oral spray with lemon water is simple,safe,effective and highly accepted by patients,and has good clinical application value. |
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