Correlation Analysis Of H-FABP,hs-CRP,and Disease Severity In Patients With Ejection Fraction-preserved Heart Failure

Heart failure（HF）is a syndrome that causes ventricular dysfunction,with pulmonary congestion and（or）systemic circulation congestion as the main clinical symptoms.Its high prevalence,high mortality,high hospitalization rate bring great burden to HF patients and society;Heart failure with preserved ejection fraction（HFpEF）is a type of heart failure with normal ejection fraction,accounting for about half of HF patients.Because of its hidden symptoms and atypical symptoms,often lead to the occurrence of missed diagnosis,misdiagnosis.Therefore,early diagnosis,to determine the disease has a potential clinical value for HFpEF.Objective Heart-type fatty acid-binding protein（H-FABP）,High Sensitive C-reactive Protein（hs-CRP）are biomarkers of myocardial damage,and the study aimed to explore the association between H-FABP、 hs-CRP and disease severity in patients with ejection fraction preserved heart failure（HFpEF）.Methods In 106 patients with preserved heart failure（HFpEF）admitted from the Hospital of Shenyang between August 2020 and August 2021,they were selected as the experimental group,and Sixty-two non-heart failure patients in the same period were included as control groups.Basic clinical data were collected from both groups.And test the N-Terminal pro-brain natriuretic peptide（NT-pro BNP）、serum creatinine,、Total triglycerides,、Total cholesterol 、 Heart-type fatty acid-binding protein（H-FABP）、 High Sensitive C-reactive Protein（hs-CRP）,and record the left ventricular ejection fraction（LVEF）、 left ventricular end-diastolic dimension（LVEDD）、left atrial internal diameter（LAD）、Interventricular septal thickness（IVSD）.Experimental group were classified as grade II（34 patients）,III（40 patients）,and IV（32 patients）,according to the New York Heart Association（NYHA）classification.The patient was followed up for 6 months from the date of discharge.The experimental group was divided into good prognosis（66）and poor prognosis（40）within 6 months.This study applied the spss26.0 software to perform the statistical analysis of the data.For the description of measurement data such as age and body mass index,data following a normal distribution are expressed by mean ± standard deviation.When comparing the measurement data of normal distribution,two independent samples applied t-test and the different data were analyzed by analysis of variance.The description of the count data is expressed by the rate.The Chi-squared test was used to test whether differences in two or more population rates or whether two variables were associated.The logistic regression analysis should be used to analyze the interrelationships between the variables.Value of subject work（ROC）curve analysis of hs-CRP and H-FABP for the diagnosis of HFpEF.P <0.05 indicates a statistically significant difference.Results1.Comparison between experimental group and control group showed that age,blood creatinine、hospital days、 hyperlipidemia、 hypertension and diabetes were significant（P <0.05）.Sex、 BMI、 smoking and alcohol history（P> 0.05）:LAD、 LVEDD and IVST were higher than the experimental group,and significant（P <0.05）.The LVEF was lower than the control group（P <0.05）and the serum H-FABP and hs-CRP were higher in the experimental group and statistically significant（P <0.05）.2.Serum levels of NT-pro BNP、 hs-CRP and H-FABP in the experimental group increased.3.Serum levels of NT-pro BNP、 H-FABP and hs-CRP were higher than those in the poor prognosis group,and the difference was statistically significant（P <0.05）.They were all three lower than before treatment and the difference was statistically significant（P <0.05）4.The Logistic regression analysis showed that age、 NT-pro BNP、 H-FABP and hs-CRP were the independent risk factors for HFpEF（p <0.05）.5.The ROC curves show AUCNT-pro BNP=0.976,AUCH-FABP=0.857,and AUChs-CRP = 0.830,indicating the corresponding value of these three measures in the diagnosis of ejection fraction-preserved heart failure.The new variable "H-FABP + hs-CRP",the area under the ROC curve is 0.916;the new variable "NT-pro BNP + H-FABP + hs-CRP",and the area under the ROC curve is 0.978,shows that the combined diagnosis somehow improves the diagnostic value of HFpEF.Conclusions1.Serum levels of hs-CRP and H-FABP were positively correlated with the condition of HFpEF patients,and they could be used as a risk factor for their occurrence.2.The hs-CRP and H-FABP provide the diagnostic value for HFpEF.