Comparative Study Of Mume Fructus And Schisandrae Chinensis Fructus In Formula Compatibility

Objective:To summarize and compare the similarities and differences of Mume Fructus and Schisandrae Chinensis Fructus in formula compatibility from the perspective of data mining and literature research,so as to provide more references for the related clinical medicine and formula compatibility research.Methods:Formulas containing Mume Fructus and formulas containing Schisandrae Chinensis Fructus in the Dictionary of Traditional Chinese Medicine Formulas(《中医方剂大辞典》)were searched and sorted out,and these formulas were entered into a software called Traditional Chinese Medicine Inheritance Support System(TCMISS)V2.5.Then the frequency statistics and association rules of TCMISS and literature research method were used to conduct data mining comparative analysis and related compatibility theory discussion on the formulas containing Mume Fructus and the formulas containing Schisandrae Chinensis Fructus.Results:Ⅰ The formulas retrieved and sorted out in this study1285 formulas containing Mume Fructus and 2846 formulas containing Schisandrae Chinensis Fructus were retrieved and analyzed in this study.In addition,88 formulas containing both Mume Fructus and Schisandrae Chinensis Fructus,13 formulas containing only Mume Fructus and 7 formulas containing only Schisandrae Chinensis Fructus have been sorted out in this study.Ⅱ Results of frequency statistics1.Among the top 10 high-frequency indications of diseases,both formulas containing Mume Fructus and formulas containing Schisandrae Chinensis Fructus are often used to treat diseases,namely cough,consumptive disease,diarrhea and wastingthirst;Formulas containing Mume Fructus are also often used to treat diseases,namely malaria,dysentery,parasitic disease,food accumulation,hemato-chezia,aggregationaccumulation;Formulas containing Schisandrae Chinensis Fructus are also often used to treat diseases,namely eye disease,dyspnea,seminal emission,infertility,impediment disease and lumbago.2.Among the top 100 high-frequency compatible drugs,both Mume Fructus and Schisandrae Chinensis Fructus are often compatible with qi-tonifying medicinal,bloodtonifying medicinal,yin-tonifying medicinal,interior-warming medicinal,phlegmresolving and cough-suppressing and panting-calming medicinal,heat-clearing medicinal,exterior-releasing medicinal,water-draining and swelling-dispersing medicinal,qi-regulating medicinal,blood-activating and stasis-resolving medicinal,wind-dampness-dispelling medicinal,etc.,such as Ginseng Radix et Rhizoma,Angelicae Sinensis Radix,Ophiopogonis Radix,Cinnamomi Cortex,Armeniacae Semen Am-arum,Rehmanniae Radix,Ephedrae Herba,Poria,Citri Reticulatae Pericarpium,Chuanxiong Rhizoma,Gentianae Macrophyllae Radix;Mume Fructus is more often compatible with heat-clearing and dampness-drying medicinal,dampnessresolving medicinal,lung-intestine astringent medicinal,emetic medicinal,purgative medicinal,digestant medicinal,hemostatic medicinal,blood-breaking masseliminating medicinal,etc.,such as Coptidis Rhizoma,Magnoliae Officinalis Cortex,Papaveris Pericarpium,Dichroae Radix,Arecae Semen,Crotonis Fructus,Massa Medicata Fermentata,Sanguisorbae Radix,Sparganii Rhizoma;Schisandrae Chinensis Fructus is more often compatible with yang-tonifying medicinal,tranquillizing medicinal,essence-securing and urination-reducing,vaginal discharge-stanching medicinal,etc.,such as Cistanches Herba,Polygalae Radix,Corni Fructus.Ⅲ Results of association rule(middle support results of this study)1.Combination medication for diseases often treated by both Mume Fructus and Schisandrae Chinensis Fructus(1)Cough: Both Mume Fructus and Schisandrae Chinensis Fructus are often compatible with Glycyrrhizae Radix et Rhizoma,Armeniacae Semen Amarum,Ginseng Radix et Rhizoma and Mori Cortex;Mume Fructus is more often compatible with Papaveris Pericarpium,Zisu and Farfarae Flos;Schisandrae Chinensis Fructus is more often compatible with Poria,Asteris Radix et Rhizoma and Citri Reticulatae Pericarpium.(2)Consumptive disease: Both Mume Fructus and Schisandrae Chinensis Fructus are often compatible with Ginseng Radix et Rhizoma,Angelicae Sinensis Radix and Cinnamomi Cortex;Mume Fructus is more often compatible with Glycyrrhizae Radix et Rhizoma,Bupleuri Radix,Trionycis Carapax and Shaoyao;Schisandrae Chinensis Fructus is more often compatible with Poria,Rehmanniae Radix Praeparata,Astragali Radix and Cistanches Herba.(3)Diarrhea: Both Mume Fructus and Schisandrae Chinensis Fructus are often compatible with Glycyrrhizae Radix et Rhizoma,Poria,Ginseng Radix et Rhizoma and Atractylodis Macrocephalae Rhizoma;Mume Fructus is more often compatible with Zingiberis Rhizoma,Coptidis Rhizoma,Angelicae Sinensis Radix and Aucklandiae Radix;Schisandrae Chinensis Fructus is more often compatible with Psoraleae Fructus,Myristicae Semen,Dioscoreae Rhizoma and Cinnamomi Cortex.(4)Wasting-thirst: Both Mume Fructus and Schisandrae Chinensis Fructus are often compatible with Glycyrrhizae Radix et Rhizoma,Ophiopogonis Radix,Ginseng Radix et Rhizoma,Trichosanthis Radix and Poria;Mume Fructus is more often compatible with Puerariae Lobatae Radix,Shaoyao and Zisu;Schisandrae Chinensis Fructus is more often compatible with Astragali Radix,Rehmanniae Radix Praeparata and Rehmanniae Radix.2.Combination medication for diseases often treated by Mume Fructus(1)Malaria: Mume Fructus is often compatible with Dichroae Radix,Glycyrrhizae Radix et Rhizoma,Anemarrhenae Rhizoma,Trionycis Carapax,Ginseng Radix et Rhizoma,Tsaoko Fructus,Bupleuri Radix and Sojae Semen Praeparatum.(2)Dysentery: Mume Fructus is often compatible with Coptidis Rhizoma,Glycyrrhizae Radix et Rhizoma,Angelicae Sinensis Radix,Zingiberis Rhizoma,Asini Corii Colla,Chebulae Fructus and Aucklandiae Radix.(3)Ascariasis: Mume Fructus is often compatible with Zanthoxyli Pericarpium,Ginseng Radix et Rhizoma,Atractylodis Macrocephalae Rhizoma,Zingiberis Rhizoma,Coptidis Rhizoma,Glycyrrhizae Radix et Rhizoma and Arecae Semen.(4)Food accumulation: Mume Fructus is often compatible with Crotonis Fructus,Caryophylli Flos,Citri Reticulatae Pericarpium,Amomi Fructus,Citri Reticulatae Pericarpium Viride,Sparganii Rhizoma and Aucklandiae Radix.(5)Hematochezia: Mume Fructus is often compatible with Coptidis Rhizoma,Angelicae Sinensis Radix,Aurantii Fructus,Sanguisorbae Radix,Glycyrrhizae Radix et Rhizoma,Scutellariae Radix and Rehmanniae Radix.(6)Aggregation-accumulation: Mume Fructus is often compatible with Sparganii Rhizoma,Crotonis Fructus,Aucklandiae Radix,Curcumae Rhizoma,Caryophylli Flos,Arecae Semen and Angelicae Sinensis Radix.(7)Emesis: Mume Fructus is often compatible with Citri Reticulatae Pericarpium,Glycyrrhizae Radix et Rhizoma,Amomi Fructus,Ginseng Radix et Rhizoma,Poria,Caryophylli Flos,Pinelliae Rhizoma and Aucklandiae Radix.(8)Sunstroke: Mume Fructus is often compatible with Glycyrrhizae Radix et Rhizoma,Puerariae Lobatae Radix,Zisu,Tsaoko Fructus,Santali Albi Lignum,Poria,Menthae Haplocalycis Herba,Ophiopogonis Radix and Amomi Fructus.3.Combination medication for diseases often treated by Schisandrae Chinensis Fructus(1)Eye disease: Schisandrae Chinensis Fructus is often compatible with Asari Radix et Rhizoma,Saposhnikoviae Radix,Plantaginis Semen,Poria,Ginseng Radix et Rhizoma,Rehmanniae Radix Praeparata and Leonuri Fructus.(2)Dyspnea: Schisandrae Chinensis Fructus is often compatible with Glycyrrhizae Radix et Rhizoma,Ginseng Radix et Rhizoma,Citri Reticulatae Pericarpium,Armeniacae Semen Amarum,Poria,Mori Cortex and Zisu.(3)Seminal emission: Schisandrae Chinensis Fructus is often compatible with Rehmanniae Radix Praeparata,Polygalae Radix,Dioscoreae Rhizoma,Poria,Ginseng Radix et Rhizoma,Cuscutae Semen and Cistanches Herba.(4)Infertility: Schisandrae Chinensis Fructus is often compatible with Rehmanniae Radix Praeparata,Niuxi,Angelicae Sinensis Radix,Poria,Ginseng Radix et Rhizoma,Cuscutae Semen and Rehmanniae Radix.(5)Spontaneous perspiration: Schisandrae Chinensis Fructus is often compatible with Glycyrrhizae Radix et Rhizoma,Astragali Radix,Atractylodis Macrocephalae Rhizoma,Ginseng Radix et Rhizoma,Angelicae Sinensis Radix,Poria and Shaoyao.(6)Night sweat: Schisandrae Chinensis Fructus is often compatible with Rehmanniae Radix Praeparata,Ginseng Radix et Rhizoma,Astragali Radix,Angelicae Sinensis Radix,Poria,Glycyrrhizae Radix et Rhizoma and Atrac-tylodis Macrocephalae Rhizoma.(7)Palpitation: Schisandrae Chinensis Fructus is often compatible with Ginseng Radix et Rhizoma,Glycyrrhizae Radix et Rhizoma,Ziziphi Spinosae Semen,Parasita Poriae,Polygalae Radix,Angelicae Sinensis Radix and Ophiopogonis Radix.(8)Insomnia: Schisandrae Chinensis Fructus is often compatible with Ziziphi Spinosae Semen,Ginseng Radix et Rhizoma,Glycyrrhizae Radix et Rhizoma,Angelicae Sinensis Radix,Astragali Radix,Polygalae Radix,Platycladi Semen,Poria and Parasita Poriae.Conclusions:1.The main similarities of Mume Fructus and Schisandrae Chinensis Fructus in formula compatibility:(1)Complementary compatibility: Both Mume Fructus and Schisandrae Chinensis Fructus are often compatible with "similar" drugs to enhance the efficacies,such as relieving cough,stopping diarrhea,promoting fluid production and eliminating dysphoric fever;Both Mume Fructus and Schisandrae Chinensis Fructus are often complementarily compatible with "different" drugs to treat synergistically diseases,such as cough,diarrhea and wasting-thirst;Both Mume Fructus and Schisandrae Chinensis Fructus are often compatible with sweet-flavor drugs to form the compatibility of sour-sweet herbs nourishing yin,so as to enhance the efficacies of sour-sweet herbs nourishing yin such as tonifying yin and promoting fluid production and lung-intestine astringency,which are often used to treat disease and syndrome,such as yin-fluid deficiency,chronic cough and chronic diarrhea.(2)Opposite compatibility: Both Mume Fructus and Schisandrae Chinensis Fructus are often compatible with acrid type of drugs to strengthen body resistance and eliminate evil;Both Mume Fructus and Schisandrae Chinensis Fructus are often compatible with raising and dispersing drugs to regulate dispersing and descending motion of lung qi;Both Mume Fructus and Schisandrae Chinensis Fructus are often compatible with ecphractic type of drugs to remove stagnation and astringency.2.The main differences of Mume Fructus and Schisandrae Chinensis Fructus in formula compatibility:(1)Compatibility of sour-sweet herbs nourishing yin: Mume Fructus is often compatible with sweet-cool type of drugs,this compatibility focuses on combining sour and sweet with cool property to benefit yin,which is good at relieving summer-heat and engendering fluid;Schisandrae Chinensis Fructus is often compatible with sweetwarm type of drugs,this compatibility focuses on combining sour and sweet with warm property to benefit yin,which is good at benefiting essence and tonifying blood.Mume Fructus is often compatible with sweet-slow and pain-relieving type of drugs,which is good at astringing liver and relieving pain;Schisandrae Chinensis Fructus is often compatible with sweet-slow and tranquillizing type of drugs,which is good at quieting spirit and stabilizing mind.(2)Compatibility of astringency: Mume Fructus is often compatible with hemostatic type of drugs,which is good at astringing intestines and stopping bleeding;Schisandrae Chinensis Fructus is often compatible with those type of drugs,such as sperm-arresting drugs,enuresis-arresting drugs and anhidrotic drugs,which is good at securing essence,reducing urination and astringing sweat.(3)Other compatibility differences: Mume Fructus is often compatible with those type of drugs,such as digestant drugs,qi-regulation drugs,drastic purgative drugs and blood-breaking drugs,which is good at calming the adverse-rising and dissipating mass;Mume Fructus is often compatible with bitter-flavor drugs to combine sour and bitter to benefit emesis and purgation,which is good at calming ascaris and preventing malaria;Schisandrae Chinensis Fructus is often compatible with those type of drugs,such as tonifying drugs,promoting inspiration drugs and asthma-relieving drugs,which is good at tonifying deficiency and stopping asthma;Schisandrae Chinensis Fructus is often compatible with those type of drugs,such as eyesight improving drugs,orifices unchoking drugs liver-kidney tonifying drugs,which is good at improving vision and removing nebula;Schisandrae Chinensis Fructus is often compatible with liver-kidney tonifying drugs,which is good at reinforcing vitality and promoting pregnancy.