Clinical Observation On The Treatment Of Oral Lichen Planus (Erosion Type) By Regulating Qi And Dispersing Blood Stasis Method

Objective: To study the clinical efficacy of "regulating qi and dispersing blood stasis method" combined with western medicine on the Erosion of Oral lichen Planus(EOLP).Objectively evaluate the effectiveness and safety of "regulating qi and dispersing blood stasis method" in the treatment of EOLP.To find effective ways to improve the clinical efficacy of EOLP,and provide a theoretical direction for the clinical use of traditional Chinese medicine(TCM)treatment of EOLP.Method: A total of 99 patients who visited the Oral Mucosal Department of Affiliated Hospital of Chengdu University of TCM and included in the standarda.The 99 patients were randomly split into the treatment group(" Taohong Siwu Decoction+ betamethasone")and the control group(betamethasone),of which 49 cases were included in the test group and 50 cases were included in the control group.Before medication,patients in both groups were given basic treatment,namely removal of dental calculus,removal of residual roots,residual crowns and other basic oral operations,in order to prevent local stimulation factors from affecting the test results.Interventional methods:experimental group: on the basis of local application of compound Betamethasone injection,was given "Taohong Siwu Decoction plus or minus" Chinese traditional medicine decoction oral treatment,usage: "Taohong Siwu Decoction plus or minus" 3 times a day,half an hour after three meals;Compound betamethasone injection was diluted 1:1 with the same amount of sterilized injection water and injected locally into the congested and erosion areas of the disease,2 weeks/time.Control group: Compound betamethasone injection and the same amount of sterilized injection water were diluted 1:1 and locally injected into the congested and erosion area of the disease,2 weeks/time.The longest intervention time of both group was 3 months.Follow-up of 6 months after treatment.Compared two groups of curative effect,as well as the integral before and after treatment symptoms and signs,visual analogue scale(visual analogue scales,VAS),TCM syndrome integral,Oral Health influence degree score(Oral Health Impact Profile,OHIP-14),relapse and adverse reactions.Results: According to data analysis,the effective rate of the treatment group was higher than that of the control group(The results of FAS dataset and PP dataset do not conflict,P < 0.05).Therefore,it is considered that the experimental intervention is more effective than the control intervention.Compare the two groups of indicators: At the end of treatment,there were differences(P < 0.05)in OHIP-14 score,VAS score,symptom score,sign score,and TCM syndrome score between the two groups.The results of FAS dataset and PP dataset do not conflict.Therefore,it can be considered that the intervention measures in the experimental group are better than the control group in reducing patients’ OHIP-14 score,VAS score,symptom score,sign score and TCM syndrome score.Indexes before and after medication: At the end of treatment,OHIP-14 score,VAS score,symptom score,sign score and TCM syndrome score in the test group are all lower than they were before,with statistical significance(The results of FAS dataset and PP dataset do not conflict,P <0.05).In the control group,OHIP-14 scores decreased after treatment,but the results of FAS dataset and PP dataset were inconsistent(in FAS dataset,P > 0.05;in PP dataset,P<0.05),it is possible that the patient loss caused the difference in the analysis of results;In the control group,VAS score,symptom score,sign score and TCM syndrome score were marked decline after treatment,the results of FAS dataset and PP dataset were do not conflict(P < 0.05).In terms of recurrence rate,the recurrence rate of the control group was higher than that of the treatment group,but the difference was not statistically significant(P > 0.05).Conclusion: In this study,99 patients with EOLP were observed clinically,the results showed that "Taohong Si Wu Decoction" combined with local injection of betamethasone was better than betamethasone alone in improving the quality of life,alleviating the clinical symptoms and signs,and reducing the TCM syndrome scores of patients with Qi stagnation and blood stasis.It is concluded that the treatment of EOLP by traditional Chinese medicine and western medicine has broad prospects and is worthy of further research and promotion.In terms of safety,no safety problems were found in both groups during and after the trial..During the trial,and no serious adverse events occurred in both group.