Efficacy Analysis Of Methylprednisolone And Compound Betamethasone Injected Into The Epidural Space In The Treatment Of Acute Herpetic Neuralgia

Objective: By comparing the clinical efficacy of equivalent dose of methylprednisolone and compound betamethasone injected into the epidural space in the treatment of acute herpetic neuralgia(AHN),this paper evaluated the efficacy and safety of two glucocorticoids in the treatment of acute herpetic neuralgia.To provide reference for rational use of hormones in clinic.Method:A retrospective collection of 60 patients who were diagnosed with acute herpes zoster(with a duration of less than 1 month and herpes located in the thoracolumbar spinal nerve innervation area)from January2020 to December 2020 in the pain ward of the First Affiliated Hospital of Chongqing Medical University and received epidural hormone injections.Among them,group M: 30 cases,the hormone injected into the epidural cavity was methylprednisolone;group B: 30 cases,the hormone injected into the epidural cavity was compound betamethasone.Record the Numeric Rating Scale(NRS)scores and the Nottingham Health Profile(NHP)scores before treatment and 1 day,1 week,1 month,and 3 months after treatment to assess the patient’s pain and life Quality situation.At the same time,record the patient’s adverse reactions and complications during the treatment.Results:1.After comparing the general data and NRS scores of patients in the two groups M and B,there was no statistically significant difference(p>0.05).2.The NRS scores of patients in the M and B groups at 1 day,1 week,1 month,and 3 months after treatment were significantly lower than the NRS score before treatment,and the difference was statistically significant(p<0.05).The NRS score of group B was significantly lower than that of group M at 1 month after treatment,and the difference was statistically significant(p<0.05).The NRS scores of the two groups at 1 day,1 week,and 3 months after treatment were not statistically significant Difference(p>0.05).3.The scores of the two dimensions of the Nottingham Health Scale for pain and sleep at 1 day,1 week,1 month,and 3 months after treatment were significantly lower than before treatment,and the difference was statistically significant(p<0.05).No significant difference was found in the scores of the Nottingham Health Scale between the two groups at the same time node in the same dimension.4.One patient in each group developed urinary retention after treatment,one patient in group M developed constipation after treatment,and two patients in group B developed constipation after treatment.All patients did not experience dural puncture,dizziness,infection,or serious nerve injury.Conclusion:The epidural injection of methylprednisolone and compound betamethasone can effectively control acute herpetic neuralgia and has good safety.The improvement of quality of life is reflected in the two dimensions of pain and sleep.The analgesic effect of compound betamethasone at 1 month after a single injection is stronger than that of methylprednisolone,but there is no significant difference in the long-term(3 months)analgesic effect between the two.