| Objectives In Tangshan city COPD patients as the research object,by four months of follow-up observation,air pollution for exacerbations of COPD patients,pulmonary function（FEV1/FVC,FEV1%and FVC,PEF）,eosinophilic airway inflammation（breath of nitric oxide（Fe NO））and inflammation index（eosinophils（EOS））,percentage of eosinophils（EOS%）,hypersensitive c-reactive protein（hs-CRP）,erythrocyte sedimentation rate（ESR）,offer a database on the effects of air pollution on COPD patients.Methods A total of 97 patients with COPD who were discharged from the Department of Respiratory and Critical Care Medicine of the Affiliated Hospital of North China University of Science and Technology from December 2018 to September 2019 were selected as study subjects,and an observation cohort was established.All patients were in stable phase and their condition was well controlled.Among them,a total of 86 patients were finally followed up.The follow-up period started from October 1,2019 and ended on January 31,2020 for a total of 4 months.Each COPD patient was followed up once a month for a period of 4W±4d.During the follow-up,the patients were tested for the following indicators:lung function（FEV1/FVC,FEV1%,FVC,PEF）,Fe NO and inflammatory indicators（EOS,EOS%,hs-CRP and ESR）.The same professional asked the subjects about the acute exacerbation of the disease.The air pollution and meteorological changes during the follow-up period were recorded,specifically:the average daily concentration of AQI,PM10,PM2.5,SO2,NO2,CO and O3,as well as temperature,humidity and wind force.To analyze the effects of different exposure levels of AQI on acute exacerbation,lung function and inflammation in patients with COPD.Statistical analysis on SPSS 23.0 has a statistical value for differences in P<0.05.Results 1 The average age in COPD patients was 64 years,an average size of 166cm and an average gravity of 63kg.In terms of sex,53 cases of lung gravity were measured in men and 33 cases.In connection with smoking,there are 25 smokers,18 smokers and 43 non-smokers.2 the average value of the AQI gradually increased,and in each month the difference in the value of the AQI has a statistical value（P<0.05）.The maximum value of each month also showed a trend of gradual increase.3 The days of AQI>100 are growing every month,and the average and maximum value is gradually increasing,but the differences have no statistical value（P>0.05）.4 Temperature and wind conditions between months are statistically justified（P<0.05）.But the mean humidity is statistically harmless（P>0.05）.5 Average monthly difference between PM2.5,CO,O3 and SO2 in terms of concentration of pollution is statistically justified（P<0.05）.The mean PM10、NO2is statistically harmless（P>0.05）.6 Apply a multidimensional linear regression model to AQI based on the variables PM10,PM2.5,CO,O3,SO2,NO2 six Pollution Intensity and Temperature,Humidity,2 Climate Factors as Independent Variables,and Analyze:PM10,PM2.5,O3,NO2,SO2,temperatures and AQI Relationship,where PM10,PM2.5 are in relation to AQI（P<0.05）,where a negative correlation between concentrations of O3,NO2,temperatures and AQI（P>0.05）.7 The frequency of acute exacerbations in COPD patients increased month by month,and there was statistical significance in the frequency of acute exacerbations among different exposure levels of AQI（P<0.05）.8 After stratified analysis according to smoking,there was statistical significance in the acute exacerbation rates of patients with COPD among passive smoking,active smoking and non-smoking（P<0.05）.9And the correlation analysis shows that the total number of acute exacerbations in COPD patients was a positive correlation between the mean AQI of each month（P<0.05）.The number of days with AQI>100 and the number of acute exacerbations in COPD patients increased month by month,but the statistical differences between them have no statistical significance（P>0.05）.10 The average value of FEV1/FVC,FEV1%and FVC is statistically significant at different levels of exposure of the AQI（P<0.05）.PEF results from patients with COPD slow no statistically value in the month（P>0.05）.11 The mean value of Fe NO in COPD patients is differences and the results are comparable（P<0.05）.EOS and EOS%results from patients with COPD slow no statistically value in the month（P>0.05）.12 The mean hs-CRP of COPD patients gradually increased with month,and the difference was comparable（P<0.05）.But ESR results from patients with COPD slow no statistically value in the month（P>0.05）.13 Analysis of multi-factor linear regression,taking into account the monthly value of the AQI and the statistical justification for the relationship between FEV1/FVC,FVC,Fe NO and hs-CRP with AQI（P<0.05）,pulmonary function index FEV1/FVC,FVC negatively related with AQI,Fe NO,hs-CRP and AQI were positively correlated,which of the indicators to FEV1/FVC and the relationship between the AQI most closely.Conclusions 1 During the observation period,AQI increased month by month.AQI of each month is most closely related to PM2.5 and is affected by a variety of factors.Therefore,it is more reasonable to study the influence of AQI on COPD patients than a single pollutant.2 With the increase of AQI,COPD patients were more likely to induce acute aggravation,and FEV1/FVC and FVC gradually decreased.With the increase of AQI,Fe NO and hs-CRP increase,indicating the intensification of airway and systemic inflammatory response in COPD patients.Figure 0;Table 15;Reference 148... |
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