| Objective:To explore the effectiveness and safety of 650nm red light in controlling myopia progression in teenagers,we observed the axial length(AL)、subfoveal choroidal thickness(SFCT)、uncorrected visual acuity(UCVA)and spherical equivalent(SE)after intervention with 650nm red light and compared them with orthokeratology.Method:1.In this study,210 cases(210 eyes)aged 8-12 years were selected,among adolescents with myopia attending the ophthalmology outpatient department of Linyi Pepole’s Hospital.Both eyes were intervened,and only the right eye data were included for statistical analysis.According to the random number table method,they were divided into red light group,orthokeratology group and control group,with 70 eyes in each group.The red light group was applied with single wavelength red light at 650nm,the orthokeratology group wore ortho-k lenses,and the control group wore conventional glasses for daily activities.The AL、SFCT、UCVA、and SE were observed before and after intervention for 1、3、6 and 12 months.2.The data were analyzed by SPSS23.0 software.The measurement data is proved to be in normal distribution by W test,which is expressed by mean standard deviation(X±S).χ~2 test is used for the comparison of gender and dominant eye among the three groups.ANOVA is used for the comparison of other baseline data,and AL、SFCT、UCVA and SE are used for the comparison of repeated measurement data.Two-factor analysis of variance is used for repeated measurement.It is proved by spherical test that all of them do not satisfy the hypothesis of spherical distribution(approximation).Greenhouse-Geisser method should be used to adjust the degree of freedom,LSD-t method should be used to test multiple comparisons between groups at the same time point,and paired t test should be used to test the comparison between groups before and after.The test level a=0.05,with P<0.05 as the difference with statistical significance.Results:1.AL:There was no significant difference in AL among the three groups before the start(F=1.741,P=0.178).Two-factor repeated measurement variance analysis showed that there was significant difference in interaction among the three groups at five time points(Fgroup=4.040,Pgroup<0.05;Ftime=114.329,Ptime<0.05;Finteraction=35.320,Pinteraction<0.05),which shows that AL changes under different intervention methods and different time,and its change trend is affected by intervention methods with time;1 month later,there was no significant difference between the control group and the red light group(t=1.95,P>0.05),but there was significant difference compared with the orthokeratology group(t=2.31,P<0.05).3,6 and 12 months later,there was significant difference in AL between the control group and the red light group and the orthokeratology group(t=2.53,2.96 and 3.50;t=2.47,3.09,3.77,all at P<0.05).1,3,6,12 months later,there was no significant difference between the red light group and the orthokeratology group(t=0.352,-0.061,0.121,0.264,P=0.725,0.952,0.904,0.793).2.SFCT:There was no significant difference in SFCT among the three groups before the start(F=1.563,P=0.212).Two-factor repeated measurement variance analysis showed that there was significant difference in interaction between the three groups at five time points(Fgrop=25.539,Pgroup<0.05;Ftime=3 19.963,Ptime<0.05;Finteraction=510.204,Pinteraction<0.05),which shows that SFCT changes under different intervention methods and different time,and its change trend is affected by intervention methods with time.1,3,6 and 12 months later,the difference between the control group and red light group and orthokeratology group was statistically significant(t=-3.29,-6.10,-8.20,-10.09,all P<0.05;t=-3.70,-6.60,-8.41,-10.43,all at P<0.05).1,3,6,12 months later,there was no significant difference between the red light group and the orthokeratology group(t=-0.418,-0.527,-0.218,-0.255,P=0.676,0.599,0.828,0.799).3.UCVA:There was no significant difference in UCVA among the three groups before the start(F=2.046,P=0.132).Two-factor repeated measurement variance analysis showed that there was significant difference in interaction between the three groups at fivetimepoints(Fgroup=2056.299,Pgroup<0.05;Ftime=352.796,Ptime<0.05;Finteraction=982.399,Pinteraction<0.05),which shows that UCVA changes under different intervention methods and different time,and its change trend is affected by intervention methods with time;1,3,6 and 12 months later,UCVA in the orthokeratology group gradually increased,and the difference was statistically significant compared with the red light group and the control group(t=-37.97,-38.66,-37.83,-40.00,all at P<0.05;t=-39.98,-46.44,-51.45,-60.11,all at P<0.05).One month later,there was no significant difference in UCVA between the red light group and the control group(t=-1.728,P=0.086),but there was significant difference in UCVA between the red light group and the control group after 3,6 and 12 months(t=-6.771,-11.687,-17.185,all at P<0.05).4.SE:There was no significant difference in SE between the three groups before the start(F=0.422,P=0.656).Two-factor repeated measurement variance analysis showed that there was significant difference in interaction between the three groups at five time points(Fgroup=610.500,Pgroup<0.05;Ftime=402.787,Ptime<0.05,Finteraction=596.916,Pinteraction<0.05),which shows that SE changes under different intervention methods and different time,and its change trend is affected by intervention methods with time;1,3,6 and 12 months later,SE in the orthokeratology group decreased gradually,and the difference were statistically significant compared with those in the red light group and the control group(t=17.86,21.33,21.87,23.30,all at P<0.05,t=18.86,23.57,25.29,27.73,all at P<0.05)One month later,there was no significant difference in SE between the red light group and the control group(t=0.996,P=0.320),but there was significant difference in SE between the red light group and the control group after 3,6 and 12 months(t=2.241,3.419 and 4.433,all at P<0.05).5.No eye complications such as photophobia,lacrimation,corneal epithelial damage,lens opacity and macular damage occurred in the red light group after the intervention.Conclusion:1.650nm red light can thicken SFCT,delay the growth of AL,and safely and effectively control the progression of myopia in adolescents;2.650nm red light can safely delay the progression of myopia without obvious adverse effect;3.650nm red light and orthokeratology have approximately the same effect in delaying myopia progression in a short period of time. |
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