| Objective To observe the curative effect of local administration of "Fushuang powder" in the treatment of bacterial vaginosis(BV),so as to provide a new drug for BV treatment and new drug research data for the study of vaginal microecology.Methods 130 cases meeting the inclusion criteria were selected,7 cases were excluded,123 cases were included,62 cases in the observation group and 61 cases in the control group.The observation group was given the traditional Chinese medicine "Fu Shuang San" in the vaginal bath and vaginal lavage.The control group was given western medicine Clindamycin Phosphate Vaginal Gel warm water wash and vaginal plug.The usage was 1times a day for 7 days.The changes of symptoms,local signs,physical and chemical examination were observed before and after treatment,and the scores were recorded and summarized.SPSS 22.0 statistical software was used for calculation and analysis.Result1.After treatment,the clearance rates of clue cells in the observation group and the control group were 88.24% and 91.67% respectively,the curative effects of the two groups were very significant(P<0.01),and there was no significant difference between the two groups(P>0.05);the clearance rates of Gardnerella were 92.86% and 100.00% respectively,the curative effects of the two groups were very significant(P<0.01),and there was no significant difference between the two groups(P>0.05);2.After treatment,leucorrhea routine of observation group and control group:(1)in the aspect of amine test,the negative conversion rate was 88.52% and 91.80% respectively,the curative effect of the two groups was very significant(P<0.01),and there was no significant difference between the two groups(P>0.05);(2)in the aspect of cleanliness,the negative conversion rate was 96.72% and 98.33% respectively,the curative effect of the two groups was very significant(P<0.01),and there was no significant difference between the two groups(P>0.05);3.After treatment,the observation group and the control group of vaginal microecology test indicators showed that:(1)p H value: normal rate was 75.47%,36.00%,the curative effect of the two groups were very significant(P<0.01),there was a significant difference between the groups(P<0.01),the observation group was better than the control group;(2)Vaginal Lactobacillus: the positive rate of the observation group increased by29.00%,while that of the control group decreased by 18.03%.The curative effect of the observation group was significant(P < 0.05),and there was significant difference between the two groups(P < 0.01);(3)hydrogen peroxide: the negative conversion rate was 29.17%and 36.17% respectively,and the curative effect of the two groups was very significant(P<0.01),and there was no significant difference between the two groups(P<0.05);(4)sialidase: the negative conversion rate of the two groups was 86.36%and 87.50%,respectively,and the curative effect was significant(P<0.05),and there was no significant difference between the two groups(P>0.05);(5)proline aminopeptidase: the positive conversion rate of the two groups was 86.36% and 87 The negative conversion rates were 54.35% and 77.50% respectively.The curative effects of the two groups were very significant(P<0.01).There was significant difference between the two groups(P<0.05).The curative effect of the control group was better.4.After treatment,the improvement rates of TCM symptoms and symptoms in the observation group and the control group were 38.71% and 36.07%,50.00% and 91.80%,61.29% and 90.16%,86.27% and 91.07% respectively,and 94.34% and 98.28%respectively(P<0.01).There was no significant difference in the amount of vaginal discharge,pruritus of vulva and vaginal discomfort after sexual intercourse between the two groups(P>0.05),but there was significant difference in the color and taste of vaginal discharge between the two groups(P<0.01),and the effect of the control group was more significant.5.After treatment,the improvement rates of gynaecological signs in the observation group and the control group were 75.81% and 73.77%,respectively.The curative effects of the two groups were very significant(P<0.01),and there was no significant difference between the two groups(P>0.05).Conclusion1.The clinical efficacy of Fu Shuang San in the treatment of BV is affirmative,and the curative effect is similar to that of Clindamycin Phosphate Vaginal Gel.2.Fu Shuang San is better than Clindamycin Phosphate Vaginal Gel in Improving vaginal microenvironment.3.The effect of Fu Shuang San is similar to that of Clindamycin Phosphate Vaginal Gel in improving the vaginal discharge,vulva itching,sexual discomfort,local signs,salivary anhydride and hydrogen peroxide in BV patients.4.The effect of Fu Shuang San on improving the color and smell of BV patients is less than that of Clindamycin Phosphate Vaginal Gel. |
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