Clinical Observation On Treatment Of Damp-heat Type Bacterial Vaginosis With Matrine Lotion Combined With Ornidazole Vaginal Suppository

ObjectiveThis study mainly used Sophora flavescens lotion combined with ornidazole vaginal suppository topical treatment of damp-heat injection type of bacterial vaginosis.By observing the changes of clinical symptoms,signs,laboratory indicators of vaginal secretions and the recurrence rate before and after treatment,the efficacy and safety were evaluated,and the mechanism of action of Sophora flavescens lotion and ornidazole vaginal suppository on bacterial vaginosis was analyzed,so as to provide the basis for the clinical use of Sophora flavescens lotion.MethodsA total of 80 patients who met the inclusion criteria were selected from the gynecological outpatient department of the First Affiliated Hospital of Anhui University of Chinese Medicine from November 2019 to October 2020.According to the principle of randomized control,the patients were divided into treatment group and control group,with 40 patients in each group.Treatment group: Sophora sophora lotion + ornidazole vaginal suppository;Control group: Ornidazole vaginal suppository.Patients in both groups were treated for 1 week and returned to the hospital 3 days after drug withdrawal.The same doctor reassessed the TCM symptom score,local signs and laboratory indicators of vaginal secretion of the patients.The recurrence rate of the cured patients was followed up for 1,2 and 3 months after treatment,and the data were statistically analyzed.Results1.In this study,a total of 80 subjects were selected and randomly divided into the treatment group and the control group,with 40 cases in each group and 6 cases in each group.Finally,38 cases were in the treatment group and 36 cases in the control group.2.Comparison of TCM syndrome scores: After treatment,there was a statistically significant difference in scores between the two groups(P < 0.05).The treatment group was better than the control group in improving TCM syndrome scores.3.Comparison of the efficacy of TCM syndromes: there was statistical difference in the efficacy of TCM syndromes between the two groups(P < 0.01);The total effective rates of the two groups were 97.37% and 77.78%,respectively,and the difference in total effective rates was statistically significant(P < 0.05).The treatment group was better than the control group in terms of TCM syndrome efficacy.4.Comparison of local sign scores: After treatment,the difference of local sign scores between the two groups was statistically significant(P < 0.05).The treatment group was better than the control group in improving local sign scores.5.Comparison of scores of related laboratory indicators: After treatment,there were statistically significant differences in scores of related laboratory indicators between the two groups(P < 0.01),and the treatment group was better than the control group in improving scores of related laboratory indicators.6.Comparison of the negative conversion rate of related laboratory indicators:there were statistically significant differences between the treatment group and the control group in the cleanliness of vaginal secretions and the negative conversion rate of leucocyte esterase(P<0.05),and the treatment group was better than the control group.There were no significant differences in vaginal p H,Lactobacillus,H2O2,cue cells,amine test,sialidase,proline aminopeptidase conversion rate between the two groups(P > 0.05).7.Comparison of clinical efficacy: the cure rate of the treatment group was 81.58%,and the cure rate of the control group was 63.89%.There was no statisticaldifference in the cure rate between the two groups(P > 0.05),indicating that there was no significant difference in clinical treatment between the two groups.8.Comparison of the recurrence rate: there was a statistical difference in the recurrence rate between the two groups after 3 months of treatment(P<0.05),and there was no statistical difference in the recurrence rate between the two groups after 1 month and 2 months of treatment(P >0.05 for all).In terms of reducing the recurrence rate,the experimental group was better than the control group.Conclusion1.In the treatment of BV,Sophora flavesifolia lotion combined with ornidazole vaginal suppository is better than ornidazole vaginal suppository alone.2.The combination of matrine lotion and ornidazole vaginal suppositories can significantly reduce the scores of TCM symptoms,local vaginal signs and main laboratory indicators of vaginal secretions in patients with bacterial vaginosis induced by dampness-heat injection.To improve the efficacy of TCM syndromes;To a certain extent,improve the clinical cure rate;Improve vaginal secretions cleanliness,improve leucocyte esterase conversion rate;3.Sophora flavescens lotion combined with ornidazole vaginal suppository can reduce the recurrence rate of damp heat injection type BV.4.There was no adverse reaction in the treatment of BV with the combination of matrine lotion and ornidazole vaginal suppository,and the drug safety was high.