Relationship Between Urinary Microalbumin/urinary Creatinine Ratio And Acute Cerebral Infarction

Objective: Urinary microalbumin / urinary creatinine ratio(UACR)plays an important role in the occurrence and development of cerebrovascular diseases.The purpose of this study was to investigate the correlation between UACR and acute cerebral infarction,etiological types,severity,short-term prognosis and degree of carotid atherosclerosis,and to evaluate its clinical application value.Methods: 113 patients with acute cerebral infarction(case group)and 109 healthy controls(control group)were selected as the research objects from December 2019 to December 2020.UACR was detected in both groups on the morning of the second day after admission.Clinical data including age,gender,smoking history,drinking history,hypertension history,diabetes history,glycosylated hemoglobin,triglyceride,total cholesterol,high density lipoprotein,low density lipoprotein,urea,creatinine,uric acid,cystatin,homocysteine and UACR were collected and analyzed statistically in both groups.Results: The levels of UACR in case group were higher than that in control group(p=0.000).Logistic regression analysis showed that UACR was a risk factor for acute cerebral infarction(OR=1.036,p=0.004).The levels of UACR was positively correlated with NIHSS score(r=0.431,p=0.000).The correlation between UACR and acute cerebral infarction is mainly reflected in the following aspects.The levels of UACR level was negatively correlated with NIHSS score difference(r=-0.243,p=0.010).The levels of UACR was positively correlated with carotid plaque stability(r=0.422,p=0.000),and was positively correlated with carotid artery stenosis(r=0.209,p=0.049).The levels of UACR was strongly associated with large artery atherosclerosis stroke(p=0.000).The ROC curve of UACR for predicting the incidence of acute cerebral infarction showed that the AUC was 0.705,the optimal cut-off value of UACR was 14.875mg/g,the sensitivity was 49.6%,and the specificity was 83.2%.Conclusions: The levels of UACR of patients with acute cerebral infarction at admission was higher than that of control group.UACR was closely related to the incidence,etiological types,severity of the disease,short-term prognosis and degree of carotid arteriosclerosis of acute cerebral infarction.UACR can be used as a reference index for early screening,evaluation and short-term prognosis of acute cerebral infarction.UACR is an independent risk factor for acute cerebral infarction.